Table 1 Clinical and biochemical characteristics of the study population
| Â | Total | Men | Women | P value |
|---|---|---|---|---|
Number | 572 | 296 | 276 | Â |
Age (years) | 45.7 ± 9.7 | 45.0 ± 9.6 | 46.5 ± 9.7 | 0.076 |
BMI (kg/m2) | 24.2 ± 3.4 | 24.9 ± 3.0 | 23.5 ± 3.6 | < 0.001 |
Fasting plasma glucose (mg/dL) | 92.0 (88.0, 98.0) | 94.0 (89.0, 100.0) | 90.5 (86.0, 96.0) | < 0.001 |
Fasting serum insulin (μU/mL) | 7.8 (6.1, 10.6) | 8.3 (6.4, 11.4) | 7.5 (5.9, 10.3) | 0.01 |
HOMAIR | 1.8 (1.4, 2.5) | 2.0 (1.5, 2.6) | 1.7 (1.3, 2.4) | < 0.001 |
Waist circumference (cm) | 84.8 ± 9.4 | 87.7 ± 7.4 | 81.7 ± 10.3 | < 0.001 |
Waist hip ratio | 0.9 ± 0.1 | 0.9 ± 0.0 | 0.8 ± 0.1 | < 0.001 |
Current smokers (%) | 19.4 | 33.8 | 4.0 | < 0.001 |
Hypertension (%) | 8.9 | 8.0 | 9.8 | 0.309 |
Diabetes mellitus (%) | 3.3 | 4.1 | 2.5 | 0.312 |
Total cholesterol (mg/dL) | 199.3 ± 35.9 | 201.6 ± 35.8 | 196.8 ± 36.0 | 0.089 |
LDL-C (mg/dL) | 116.5 ± 32.9 | 119.4 ± 33.7 | 113.5 ± 31.8 | 0.036 |
HDL-C (mg/dL) | 54.0 (45.0, 65.0) | 48.0 (42.0, 55.0) | 61.0 (51.3, 71.0) | < 0.001 |
TG (mg/dL) | 114.5 (76.0, 164.8) | 135.0 (92.0, 203.8) | 91.0 (67.0, 134.8) | < 0.001 |
CRP (mg/L) | 0.6 (0.3, 1.2) | 0.6 (0.3, 1.2) | 0.5 (0.2, 1.2) | 0.098 |
Fibrinogen (mg/dL) | 260.3 ± 67.3 | 256.9 ± 68.8 | 263.8 ± 65.6 | 0.187 |
sE-selectin(ng/L) | 49.9 (35.6, 64.3) | 57.0 (41.6, 73.5) | 42.5 (31.1, 54.7) | < 0.001 |
sP-selectin(ng/mL) | 95.0 (65.9, 169.7) | 103.9 (70.0, 187.8) | 86.7 (60.0, 151.3) | 0.005 |
SAA (μmol/L) | 3.6 (1.7, 6.0) | 3.3 (1.6, 6.0) | 3.6 (1.7, 6.1) | 0.399 |
sICAM1 (ng/L) | 228.0 (179.9, 275.1) | 232.0 (182.0, 283.6) | 225.1 (175.8, 271.6) | 0.776 |
sVCAM1(ng/L) | 477.0 (406.0, 545.0) | 479.0 (399.0, 555.0) | 476.0 (415.0, 540.0) | 0.81 |
MMP-1 (pg/mL) | 188.3 (102.1, 398.8) | 184.8 (110.8, 404.4) | 189.0 (96.2, 398.4) | 0.601 |
MMP-2 (ng/mL) | 122.2 (103.1, 140.4) | 118.9 (98.7, 137.5) | 124.9 (106.9, 146.1) | 0.018 |
MMP-9 (mg/L) | 109.9 (73.8, 167.3) | 120.5 (83.3, 184.6) | 99.4 (66.1, 150.2) | 0.003 |
MCP-1 (pg/mL) | 59.8 (43.6, 83.5) | 62.6 (46.1, 86.7) | 56.2 (40.9, 80.8) | 0.005 |
sTNFRII (pg/mL) | 3095.8 (2635.9, 3708.9) | 3120.2 (2742.4, 3726.3) | 3066.8 (2528.2, 3700.6) | 0.018 |
8-OHdG/creatinine (ng/mg) | 32.6 (24.3, 44.2) | 30.4 (22.5, 40.0) | 35.2 (26.8, 48.4) | < 0.001 |
LIPC-rs2043085 | Â | Â | Â | Â |
 CC | 159 (28.3%) | 73 (25.2%) | 86 (31.6%) | 0.198 |
 TC | 284 (50.5%) | 150 (51.7%) | 134 (49.3%) |  |
 TT | 119 (21.2%) | 67 (23.1%) | 52 (19.1%) |  |
LIPC-rs1532085 | Â | Â | Â | Â |
 GG | 162 (28.8%) | 74 (25.5%) | 88 (32.2%) | 0.200 |
 GA | 287 (51.0%) | 153 (52.8%) | 134 (49.1%) |  |
 AA | 114 (20.2%) | 63 (21.7%) | 51 (18.7%) |  |
LIPC-rs1800588 | Â | Â | Â | Â |
 CC | 228 (40.5%) | 125 (43.1%) | 103 (37.7%) | 0.659 |
 TC | 261 (46.4%) | 128 (44.1%) | 133 (48.7%) |  |
 TT | 74 (13.1%) | 37 (12.8%) | 37 (13.6%) |  |