Table 2 Associations between the LIPC SNPs and lipid profiles and urinary 8OHdG levels
| Genotypes | MM | Mm | mm |
P1
(adjusted P) |
P2
(adjusted P) |
|---|---|---|---|---|---|
| rs2043085, number | 159 | 284 | 119 | ||
| Total cholesterol (mg/dL) | 198.8 ± 39.7 | 198.3 ± 33.6 | 201.6 ± 35.8 | 0.435 | |
| LDL-C (mg/dL) | 120.2 ± 37.9 | 114.8 ± 30.2 | 115.2 ± 31.4 | 0.248 | |
| HDL-C (mg/dL) | 53.0 (44.0, 64.0) | 53.0 (44.0, 66.0) | 54.0 (45.0, 65.0) | 0.039 |
a 3 × 10− 4 (5.4 × 10− 4) |
| TG (mg/dL) | 102.0 (71.0, 151.0) | 111.0 (75.3, 161.8) | 129.0 (90.0, 186.0) |
0.007 (0.021) |
b6 × 10−5 (2.7 × 10− 4) |
| 8-OHdG (ng/mg) | 32.9 (21.8, 44.1) | 31.6 (24.7, 43.0) | 35.9 (27.4, 47.6) |
0.001 (0.015) |
a4 × 10− 4 (6.0 × 10− 4) |
| rs1532085, number | 162 | 287 | 114 | ||
| Total cholesterol (mg/dL) | 198.1 ± 40.0 | 198.6 ± 33.3 | 201.7 ± 35.9 | 0.309 | |
| LDL-C (mg/dL) | 119.5 ± 38.2 | 115.2 ± 30.0 | 114.9 ± 31.3 | 0.348 | |
| HDL-C (mg/dL) | 53.0 (44.0, 63.3) | 53.0 (44.0, 66.0) | 54.0 (45.0, 65.3) | 0.035 |
a2 × 10−4 (4.5 × 10− 4) |
| TG (mg/dL) | 101.5 (70.8, 151.5) | 112.0 (76.0, 161.0) | 129.0 (90.0, 196.3) |
0.006 (0.021) |
b5 × 10−5 (2.7 × 10− 4) |
| 8-OHdG (ng/mg) | 32.6 (22.4, 44.1) | 32.1 (24.8, 43.5) | 35.8 (26.9, 46.6) |
0.002 (0.015) |
a0.001 (0.001) |
| rs1800588, number | 228 | 261 | 74 | ||
| Total cholesterol (mg/dL) | 195.2 ± 35.3 | 200.3 ± 36.1 | 206.7 ± 35.7 |
0.003 (0.015) | |
| LDL-C (mg/dL) | 115.2 ± 33.6 | 116.6 ± 32.7 | 118.9 ± 31.1 | 0.196 | |
| HDL-C (mg/dL) | 52.0 (44.3, 64.0) | 54.0 (44.0, 65.0) | 56.5 (46.8, 69.0) | 0.089 |
a0.002 (0.002) |
| TG (mg/dL) | 107.0 (72.3, 161.8) | 116.0 (76.0, 164.5) | 118.5 (79.0, 183.5) |
0.009 (0.023) |
b2 × 10−4 (4.5 × 10− 4) |
| 8-OHdG (ng/mg) | 32.4 (24.3, 43.3) | 33.7 (25.5, 45.1) | 29.7 (22.3, 39.4) | 0.155 | a0.177 |