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Table 2 Associations between the LIPC SNPs and lipid profiles and urinary 8OHdG levels

From: Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population

Genotypes MM Mm mm P1 (adjusted P) P2 (adjusted P)
rs2043085, number 159 284 119   
Total cholesterol (mg/dL) 198.8 ± 39.7 198.3 ± 33.6 201.6 ± 35.8 0.435  
LDL-C (mg/dL) 120.2 ± 37.9 114.8 ± 30.2 115.2 ± 31.4 0.248  
HDL-C (mg/dL) 53.0 (44.0, 64.0) 53.0 (44.0, 66.0) 54.0 (45.0, 65.0) 0.039 a 3 × 10− 4 (5.4 × 10− 4)
TG (mg/dL) 102.0 (71.0, 151.0) 111.0 (75.3, 161.8) 129.0 (90.0, 186.0) 0.007 (0.021) b6 × 10−5 (2.7 × 10− 4)
8-OHdG (ng/mg) 32.9 (21.8, 44.1) 31.6 (24.7, 43.0) 35.9 (27.4, 47.6) 0.001 (0.015) a4 × 10− 4 (6.0 × 10− 4)
rs1532085, number 162 287 114   
Total cholesterol (mg/dL) 198.1 ± 40.0 198.6 ± 33.3 201.7 ± 35.9 0.309  
LDL-C (mg/dL) 119.5 ± 38.2 115.2 ± 30.0 114.9 ± 31.3 0.348  
HDL-C (mg/dL) 53.0 (44.0, 63.3) 53.0 (44.0, 66.0) 54.0 (45.0, 65.3) 0.035 a2 × 10−4 (4.5 × 10− 4)
TG (mg/dL) 101.5 (70.8, 151.5) 112.0 (76.0, 161.0) 129.0 (90.0, 196.3) 0.006 (0.021) b5 × 10−5 (2.7 × 10− 4)
8-OHdG (ng/mg) 32.6 (22.4, 44.1) 32.1 (24.8, 43.5) 35.8 (26.9, 46.6) 0.002 (0.015) a0.001 (0.001)
rs1800588, number 228 261 74   
Total cholesterol (mg/dL) 195.2 ± 35.3 200.3 ± 36.1 206.7 ± 35.7 0.003 (0.015)  
LDL-C (mg/dL) 115.2 ± 33.6 116.6 ± 32.7 118.9 ± 31.1 0.196  
HDL-C (mg/dL) 52.0 (44.3, 64.0) 54.0 (44.0, 65.0) 56.5 (46.8, 69.0) 0.089 a0.002 (0.002)
TG (mg/dL) 107.0 (72.3, 161.8) 116.0 (76.0, 164.5) 118.5 (79.0, 183.5) 0.009 (0.023) b2 × 10−4 (4.5 × 10− 4)
8-OHdG (ng/mg) 32.4 (24.3, 43.3) 33.7 (25.5, 45.1) 29.7 (22.3, 39.4) 0.155 a0.177
  1. Abbreviations as in Table 1
  2. P1: adjusted for age, sex, BMI, and current smoke; P2: P values of associations between SNPs and HDL-C, 8-OHdG or TG levels after adjustment for age, sex, BMI, current smoke and TG (a) or HDL-C (b) levels
  3. MM: homozygosity of major allele, Mm: heterozygosity, mm: homozygosity of minor allele
  4. Adjusted P values were shown with False Discovery Rate correction of P1 and P2 values, and only significant P values were demonstrated