Table 2 Associations between the LIPC SNPs and lipid profiles and urinary 8OHdG levels

rs2043085, number

159

284

119

Total cholesterol (mg/dL)

198.8 ± 39.7

198.3 ± 33.6

201.6 ± 35.8

0.435

LDL-C (mg/dL)

120.2 ± 37.9

114.8 ± 30.2

115.2 ± 31.4

0.248

HDL-C (mg/dL)

53.0 (44.0, 64.0)

53.0 (44.0, 66.0)

54.0 (45.0, 65.0)

0.039

^a 3 × 10^− 4

(5.4 × 10^− 4)

TG (mg/dL)

102.0 (71.0, 151.0)

111.0 (75.3, 161.8)

129.0 (90.0, 186.0)

0.007

(0.021)

^b6 × 10⁻⁵

(2.7 × 10^− 4)

8-OHdG (ng/mg)

32.9 (21.8, 44.1)

31.6 (24.7, 43.0)

35.9 (27.4, 47.6)

0.001

(0.015)

^a4 × 10^− 4

(6.0 × 10^− 4)

rs1532085, number

162

287

114

Total cholesterol (mg/dL)

198.1 ± 40.0

198.6 ± 33.3

201.7 ± 35.9

0.309

LDL-C (mg/dL)

119.5 ± 38.2

115.2 ± 30.0

114.9 ± 31.3

0.348

HDL-C (mg/dL)

53.0 (44.0, 63.3)

53.0 (44.0, 66.0)

54.0 (45.0, 65.3)

0.035

^a2 × 10⁻⁴

(4.5 × 10^− 4)

TG (mg/dL)

101.5 (70.8, 151.5)

112.0 (76.0, 161.0)

129.0 (90.0, 196.3)

0.006

(0.021)

^b5 × 10⁻⁵

(2.7 × 10^− 4)

8-OHdG (ng/mg)

32.6 (22.4, 44.1)

32.1 (24.8, 43.5)

35.8 (26.9, 46.6)

0.002

(0.015)

^a0.001

(0.001)

rs1800588, number

228

261

74

Total cholesterol (mg/dL)

195.2 ± 35.3

200.3 ± 36.1

206.7 ± 35.7

0.003

(0.015)

LDL-C (mg/dL)

115.2 ± 33.6

116.6 ± 32.7

118.9 ± 31.1

0.196

HDL-C (mg/dL)

52.0 (44.3, 64.0)

54.0 (44.0, 65.0)

56.5 (46.8, 69.0)

0.089

^a0.002

(0.002)

TG (mg/dL)

107.0 (72.3, 161.8)

116.0 (76.0, 164.5)

118.5 (79.0, 183.5)

0.009

(0.023)

^b2 × 10⁻⁴

(4.5 × 10^− 4)

8-OHdG (ng/mg)

32.4 (24.3, 43.3)

33.7 (25.5, 45.1)

29.7 (22.3, 39.4)

0.155

^a0.177