Table 3 Subgroup analysis for the associations between the LIPC SNPs and lipid profiles and urinary 8OHdG levels according to sex
Sex | Male | Female | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Genotypes (N) | MM | Mm | mm | P1 (adjusted P) | P2 (adjusted P) | MM | Mm | mm | P1 (adjusted P) | P2 (adjusted P) |
rs2043085 number | 73 | 150 | 67 | Â | Â | 86 | 134 | 52 | Â | Â |
Total cholesterol (mg/dL) | 199.9 ± 42.2 | 199.6 ± 33.8 | 205.2 ± 32.4 | 0.300 |  | 197.9 ± 37.8 | 196.9 ± 33.4 | 196.9 ± 39.5 | 0.781 |  |
LDL-C (mg/dL) | 125.4 ± 40.3 | 115.8 ± 31.4 | 118.5 ± 29.8 | 0.339 |  | 115.8 ± 35.5 | 113.6 ± 28.7 | 110.9 ± 33.2 | 0.299 |  |
HDL-C (mg/dL) | 47.0 (40.5, 53.5) | 49.0 (42.8, 55.3) | 50.0 (43.0, 56.0) | 0.194 | a0.005 (0.006) | 59.5 (51.0, 70.3) | 62.0 (52.0, 71.0) | 62.0 (52.3, 70.8) | 0.081 | a0.028 |
TG (mg/dL) | 126.0 (78.5, 162.5) | 135.5 (93.0, 222.3) | 150.0 (105.0, 218.0) | 0.005 (0.015) | b2 × 10−4 (6 × 10− 4) | 90.0 (64.0, 135.0) | 86.5 (65.8, 134.3) | 105.0 (75.8, 142.0) | 0.629 | b0.151 |
8OHdG (ng/mg) | 29.6 (20.6, 37.3) | 30.0 (22.5, 38.8) | 35.1 (24.3, 45.1) | 0.001 (0.015) | a0.001 (0.002) | 35.2 (23.3, 48.8) | 34.5 (26.5, 45.9) | 37.7 (28.2, 53.8) | 0.088 | a0.088 |
rs1532085 number | 74 | 153 | 63 | Â | Â | 88 | 134 | 51 | Â | Â |
Total cholesterol (mg/dL) | 198.8 ± 42.6 | 199.9 ± 33.4 | 206.0 ± 32.2 | 0.173 |  | 197.4 ± 38.0 | 197.1 ± 33.2 | 196.3 ± 39.7 | 0.762 |  |
LDL-C (mg/dL) | 124.1 ± 40.9 | 116.3 ± 31.2 | 118.7 ± 29.4 | 0.516 |  | 115.5 ± 35.6 | 113.8 ± 28.5 | 110.3 ± 33.2 | 0.278 |  |
HDL-C (mg/dL) | 46.5 (40.0, 53.3) | 49.0 (43.0, 55.8) | 50.0 (41.0, 56.0) | 0.183 | a0.004 (0.005) | 60.0 (51.0, 69.8) | 62.0 (51.0, 71.0) | 64.0 (53.0, 71.0) | 0.079 | a0.025 |
TG (mg/dL) | 128.0 (78.8, 165.0) | 131.0 (93.0, 220.0) | 152.0 (105.0, 218.0) | 0.005 (0.015) | b1.5 × 10−4 (4.5 × 10− 4) | 90.0 (64.0, 133.8) | 86.5 (66.8, 136.0) | 104.0 (75.0, 142.0) | 0.605 | b0.140 |
8OHdG (ng/mg) | 29.9 (20.2, 38.0) | 30.0 (22.8, 38.9) | 34.4 (23.5, 44.8) | 0.007 (0.018) | a0.004 (0.005) | 34.9 (23.2, 48.3) | 34.8 (26.7, 47.3) | 37.5 (28.1, 50.8) | 0.085 | a0.086 |
rs1800588 number | 125 | 128 | 37 | Â | Â | 103 | 133 | 37 | Â | Â |
Total cholesterol (mg/dL) | 195.8 ± 36.6 | 202.4 ± 34.5 | 213.3 ± 34.3 | 0.003 (0.015) |  | 194.5 ± 33.8 | 198.3 ± 37.5 | 200.0 ± 36.3 | 0.244 |  |
LDL-C (mg/dL) | 118.0 ± 35.9 | 118.6 ± 32.2 | 122.5 ± 31.3 | 0.336 |  | 111.9 ± 30.4 | 114.7 ± 33.1 | 115.3 ± 31.0 | 0.402 |  |
HDL-C (mg/dL) | 47.0 (42.5, 53.0) | 48.0 (41.0, 57.0) | 53.0 (43.0, 59.0) | 0.100 | a0.001 (0.002) | 62.0 (50.0, 70.0) | 61.0 (52.0, 70.0) | 63.0 (54.5, 73.5) | 0.423 | a0.27 |
TG (mg/dL) | 120.0 (89.0, 173.5) | 145.5 (97.5, 197.8) | 152.0 (106.0, 234.5) | 0.004 (0.015) | b4.9 × 10−5 (3.6 × 10− 4) | 90.0 (64.0, 140.0) | 95.0 (67.5, 134.0) | 87.0 (65.5, 135.0) | 0.682 | b0.387 |
8OHdG (ng/mg) | 31.6 (24.4, 39.0) | 29.9 (21.1, 42.8) | 25.6 (21.3, 37.8) | 0.098 | a0.134 | 34.4 (24.1, 49.2) | 37.3 (28.7, 49.6) | 30.7 (23.3, 43.4) | 0.698 | a0.699 |