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Table 3 Subgroup analysis for the associations between the LIPC SNPs and lipid profiles and urinary 8OHdG levels according to sex

From: Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population

Sex Male Female
Genotypes (N) MM Mm mm P1 (adjusted P) P2 (adjusted P) MM Mm mm P1 (adjusted P) P2 (adjusted P)
rs2043085 number 73 150 67    86 134 52   
Total cholesterol (mg/dL) 199.9 ± 42.2 199.6 ± 33.8 205.2 ± 32.4 0.300   197.9 ± 37.8 196.9 ± 33.4 196.9 ± 39.5 0.781  
LDL-C (mg/dL) 125.4 ± 40.3 115.8 ± 31.4 118.5 ± 29.8 0.339   115.8 ± 35.5 113.6 ± 28.7 110.9 ± 33.2 0.299  
HDL-C (mg/dL) 47.0 (40.5, 53.5) 49.0 (42.8, 55.3) 50.0 (43.0, 56.0) 0.194 a0.005 (0.006) 59.5 (51.0, 70.3) 62.0 (52.0, 71.0) 62.0 (52.3, 70.8) 0.081 a0.028
TG (mg/dL) 126.0 (78.5, 162.5) 135.5 (93.0, 222.3) 150.0 (105.0, 218.0) 0.005 (0.015) b2 × 10−4 (6 × 10− 4) 90.0 (64.0, 135.0) 86.5 (65.8, 134.3) 105.0 (75.8, 142.0) 0.629 b0.151
8OHdG (ng/mg) 29.6 (20.6, 37.3) 30.0 (22.5, 38.8) 35.1 (24.3, 45.1) 0.001 (0.015) a0.001 (0.002) 35.2 (23.3, 48.8) 34.5 (26.5, 45.9) 37.7 (28.2, 53.8) 0.088 a0.088
rs1532085 number 74 153 63    88 134 51   
Total cholesterol (mg/dL) 198.8 ± 42.6 199.9 ± 33.4 206.0 ± 32.2 0.173   197.4 ± 38.0 197.1 ± 33.2 196.3 ± 39.7 0.762  
LDL-C (mg/dL) 124.1 ± 40.9 116.3 ± 31.2 118.7 ± 29.4 0.516   115.5 ± 35.6 113.8 ± 28.5 110.3 ± 33.2 0.278  
HDL-C (mg/dL) 46.5 (40.0, 53.3) 49.0 (43.0, 55.8) 50.0 (41.0, 56.0) 0.183 a0.004 (0.005) 60.0 (51.0, 69.8) 62.0 (51.0, 71.0) 64.0 (53.0, 71.0) 0.079 a0.025
TG (mg/dL) 128.0 (78.8, 165.0) 131.0 (93.0, 220.0) 152.0 (105.0, 218.0) 0.005 (0.015) b1.5 × 10−4 (4.5 × 10− 4) 90.0 (64.0, 133.8) 86.5 (66.8, 136.0) 104.0 (75.0, 142.0) 0.605 b0.140
8OHdG (ng/mg) 29.9 (20.2, 38.0) 30.0 (22.8, 38.9) 34.4 (23.5, 44.8) 0.007 (0.018) a0.004 (0.005) 34.9 (23.2, 48.3) 34.8 (26.7, 47.3) 37.5 (28.1, 50.8) 0.085 a0.086
rs1800588 number 125 128 37    103 133 37   
Total cholesterol (mg/dL) 195.8 ± 36.6 202.4 ± 34.5 213.3 ± 34.3 0.003 (0.015)   194.5 ± 33.8 198.3 ± 37.5 200.0 ± 36.3 0.244  
LDL-C (mg/dL) 118.0 ± 35.9 118.6 ± 32.2 122.5 ± 31.3 0.336   111.9 ± 30.4 114.7 ± 33.1 115.3 ± 31.0 0.402  
HDL-C (mg/dL) 47.0 (42.5, 53.0) 48.0 (41.0, 57.0) 53.0 (43.0, 59.0) 0.100 a0.001 (0.002) 62.0 (50.0, 70.0) 61.0 (52.0, 70.0) 63.0 (54.5, 73.5) 0.423 a0.27
TG (mg/dL) 120.0 (89.0, 173.5) 145.5 (97.5, 197.8) 152.0 (106.0, 234.5) 0.004 (0.015) b4.9 × 10−5 (3.6 × 10− 4) 90.0 (64.0, 140.0) 95.0 (67.5, 134.0) 87.0 (65.5, 135.0) 0.682 b0.387
8OHdG (ng/mg) 31.6 (24.4, 39.0) 29.9 (21.1, 42.8) 25.6 (21.3, 37.8) 0.098 a0.134 34.4 (24.1, 49.2) 37.3 (28.7, 49.6) 30.7 (23.3, 43.4) 0.698 a0.699
  1. P1: adjusted for age, sex, BMI, current smoke; P2: P values of associations between SNPs and HDL-C, 8-OHdG or TG after adjusted for age, sex, BMI, current smoke and TG (a) or HDL-C (b)
  2. MM: homozygosity of major allele, Mm: heterozygosity, mm: homozygosity of minor allele
  3. Adjusted P values were shown with False Discovery Rate correction of P1 and P2 values, and only significant P values were demonstrated