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Table 4 Subgroup analysis for the associations between the LIPC SNPs and lipid profiles and urinary 8OHdG levels according to obesity

From: Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population

Obesity Obese Non-obese
Genotypes MM Mm mm P1 (adjusted P) P2 (adjusted P) MM Mm mm P1 (adjusted P) P2 (adjusted P)
rs2043085 number 41 123 50    118 161 69   
Total cholesterol (mg/dL) 204.0 ± 41.3 201.0 ± 34.0 205.6 ± 35.4 0.6   197.0 ± 39.2 196.3 ± 33.2 198.7 ± 36.0 0.538  
LDL-C (mg/dL) 127.0 ± 39.8 116.3 ± 29.6 121.8 ± 31.6 0.754   117.8 ± 37.2 113.6 ± 30.6 110.3 ± 30.6 0.261  
HDL-C (mg/dL) 46.0 (40.5, 54.5) 49.0 (41.0, 59.0) 55.0 (47.0, 60.3) 0.001 (0.005) a4 × 10−4 (0.002) 56.5 (46.8, 66.0) 58.0 (47.5, 70.0) 52.0 (44.0, 68.0) 0.717 a0.028 (0.032)
TG (mg/dL) 138.0 (103.0, 173.5) 141.0 (97.0, 223.0) 133.0 (91.8, 174.3) 0.995 b0.181 89.0 (64.8, 145.8) 92.0 (66.5, 128.5) 123.0 (88.0, 211.5) 0.002 (0.015) b1 × 10−4 (5 × 10−4)
8OHdG (ng/mg) 30.0 (19.1, 37.7) 31.1 (23.8, 40.2) 36.3 (25.6, 55.1) 0.002 (0.008) a0.003 (0.009) 33.3 (23.1, 44.7) 32.7 (24.7, 44.0) 35.9 (27.8, 45.9) 0.035 a0.026 (0.032)
rs1532085 number 42 124 48    120 163 66   
Total cholesterol (mg/dL) 202.1 ± 42.3 201.6 ± 33.7 205.8 ± 35.3 0.398   196.6 ± 39.3 196.3 ± 33.0 198.7 ± 36.3 0.515  
LDL-C (mg/dL) 124.9 ± 41.0 117.2 ± 29.3 121.7 ± 31.4 0.974   117.6 ± 37.2 113.7 ± 30.5 110.0 ± 30.6 0.270  
HDL-C (mg/dL) 46.0 (40.0, 54.3) 49.5 (42.0, 59.0) 55.0 (47.0, 60.8) 0.001 (0.005) a3 × 10−4 (0.002) 57.0 (47.0, 65.8) 57.0 (47.0, 70.0) 52.5 (43.8, 68.0) 0.708 a0.028 (0.032)
TG (mg/dL) 141.0 (105.5, 176.8) 140.5 (96.3, 220.5) 133.0 (94.0, 176.8) 0.968 b0.160 89.0 (64.3, 143.3) 93.0 (67.0, 135.0) 118.5 (85.8, 210.3) 0.002 (0.015) b1.4 × 10−4 (5 × 10−4)
8OHdG (ng/mg) 30.7 (18.8, 39.0) 31.1 (24.0, 40.8) 35.8 (24.1, 47.3) 0.017 (0.043) a0.017 (0.031) 33.1 (23.1, 44.5) 33.0 (25.1, 44.3) 35.5 (27.5, 46.6) 0.030 a0.021 (0.032)
rs1800588 number 91 97 26    137 164 48   
Total cholesterol (mg/dL) 193.5 ± 36.6 206.4 ± 32.5 220.4 ± 36.4 2 × 10−4 (0.003)   196.3 ± 34.5 196.7 ± 37.7 199.3 ± 33.4 0.484  
LDL-C (mg/dL) 113.2 ± 33.7 122.4 ± 30.3 132.0 ± 31.0 0.003 (0.009)   116.6 ± 33.5 113.2 ± 33.6 111.8 ± 29.2 0.538  
HDL-C (mg/dL) 50.0 (42.0, 56.0) 51.0 (43.0, 61.0) 53.5 (43.0, 58.5) 0.367 a0.060 55.0 (46.0, 68.0) 57.0 (47.0, 67.8) 62.0 (50.3, 72.5) 0.136 a0.012 (0.032)
TG (mg/dL) 132.0 (86.0, 174.0) 140.0 (105.5, 186.5) 141.5 (119.3, 216.8) 0.028 b0.006 (0.014) 93.0 (67.0, 134.5) 98.5 (68.5, 154.5) 90.5 (67.3, 167.3) 0.156 b0.014 (0.032)
8OHdG (ng/mg) 32.0 (23.3, 42.7) 31.5 (22.2, 43.3) 30.1 (19.1, 38.3) 0.13 a0.144 33.0 (24.9, 43.9) 34.7 (26.2, 46.0) 29.0 (23.1, 41.7) 0.59 a0.619
  1. P1: adjusted for age, sex, BMI, current smoke; P2: P values of associations between SNPs and HDL-C, 8-OHdG or TG levels after adjusted for age, sex, BMI, current smoke and TG (a) or HDL-C (b)
  2. MM: homozygosity of major allele, Mm: heterozygosity, mm: homozygosity of minor allele
  3. Adjusted P values were shown with False Discovery Rate correction of P1 and P2 values, and only significant P values were demonstrated