Table 4 Subgroup analysis for the associations between the LIPC SNPs and lipid profiles and urinary 8OHdG levels according to obesity

rs2043085

number

41

123

50

118

161

69

Total cholesterol (mg/dL)

204.0 ± 41.3

201.0 ± 34.0

205.6 ± 35.4

0.6

197.0 ± 39.2

196.3 ± 33.2

198.7 ± 36.0

0.538

LDL-C (mg/dL)

127.0 ± 39.8

116.3 ± 29.6

121.8 ± 31.6

0.754

117.8 ± 37.2

113.6 ± 30.6

110.3 ± 30.6

0.261

HDL-C (mg/dL)

46.0 (40.5, 54.5)

49.0 (41.0, 59.0)

55.0 (47.0, 60.3)

0.001

(0.005)

^a4 × 10⁻⁴

(0.002)

56.5 (46.8, 66.0)

58.0 (47.5, 70.0)

52.0 (44.0, 68.0)

0.717

^a0.028

(0.032)

TG (mg/dL)

138.0 (103.0, 173.5)

141.0 (97.0, 223.0)

133.0 (91.8, 174.3)

0.995

^b0.181

89.0 (64.8, 145.8)

92.0 (66.5, 128.5)

123.0 (88.0, 211.5)

0.002 (0.015)

^b1 × 10⁻⁴

(5 × 10⁻⁴)

8OHdG (ng/mg)

30.0 (19.1, 37.7)

31.1 (23.8, 40.2)

36.3 (25.6, 55.1)

0.002 (0.008)

^a0.003

(0.009)

33.3 (23.1, 44.7)

32.7 (24.7, 44.0)

35.9 (27.8, 45.9)

0.035

^a0.026

(0.032)

rs1532085

number

42

124

48

120

163

66

Total cholesterol (mg/dL)

202.1 ± 42.3

201.6 ± 33.7

205.8 ± 35.3

0.398

196.6 ± 39.3

196.3 ± 33.0

198.7 ± 36.3

0.515

LDL-C (mg/dL)

124.9 ± 41.0

117.2 ± 29.3

121.7 ± 31.4

0.974

117.6 ± 37.2

113.7 ± 30.5

110.0 ± 30.6

0.270

HDL-C (mg/dL)

46.0 (40.0, 54.3)

49.5 (42.0, 59.0)

55.0 (47.0, 60.8)

0.001 (0.005)

^a3 × 10⁻⁴

(0.002)

57.0 (47.0, 65.8)

57.0 (47.0, 70.0)

52.5 (43.8, 68.0)

0.708

^a0.028

(0.032)

TG (mg/dL)

141.0 (105.5, 176.8)

140.5 (96.3, 220.5)

133.0 (94.0, 176.8)

0.968

^b0.160

89.0 (64.3, 143.3)

93.0 (67.0, 135.0)

118.5 (85.8, 210.3)

0.002 (0.015)

^b1.4 × 10⁻⁴

(5 × 10⁻⁴)

8OHdG (ng/mg)

30.7 (18.8, 39.0)

31.1 (24.0, 40.8)

35.8 (24.1, 47.3)

0.017 (0.043)

^a0.017

(0.031)

33.1 (23.1, 44.5)

33.0 (25.1, 44.3)

35.5 (27.5, 46.6)

0.030

^a0.021

(0.032)

rs1800588

number

91

97

26

137

164

48

Total cholesterol (mg/dL)

193.5 ± 36.6

206.4 ± 32.5

220.4 ± 36.4

2 × 10⁻⁴ (0.003)

196.3 ± 34.5

196.7 ± 37.7

199.3 ± 33.4

0.484

LDL-C (mg/dL)

113.2 ± 33.7

122.4 ± 30.3

132.0 ± 31.0

0.003 (0.009)

116.6 ± 33.5

113.2 ± 33.6

111.8 ± 29.2

0.538

HDL-C (mg/dL)

50.0 (42.0, 56.0)

51.0 (43.0, 61.0)

53.5 (43.0, 58.5)

0.367

^a0.060

55.0 (46.0, 68.0)

57.0 (47.0, 67.8)

62.0 (50.3, 72.5)

0.136

^a0.012

(0.032)

TG (mg/dL)

132.0 (86.0, 174.0)

140.0 (105.5, 186.5)

141.5 (119.3, 216.8)

0.028

^b0.006

(0.014)

93.0 (67.0, 134.5)

98.5 (68.5, 154.5)

90.5 (67.3, 167.3)

0.156

^b0.014

(0.032)

8OHdG (ng/mg)

32.0 (23.3, 42.7)

31.5 (22.2, 43.3)

30.1 (19.1, 38.3)

0.13

^a0.144

33.0 (24.9, 43.9)

34.7 (26.2, 46.0)

29.0 (23.1, 41.7)

0.59

^a0.619