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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway

Fig. 2

Inhibition of FASN expression suppresses the activity of the Akt/ERK signaling pathway. Target protein expression of A549 cells (left panel) and NCI-H1299 cells (right panel) were detected by western-blot. Compared to the blank and control groups, the expressions of p-Akt and p-ERK in the experimental group were significantly inhibited. However, there were no statistically significant differences in the t-Akt and t-ERK expressions of each group. Importantly, the expression of PKM2 but not HK2 (both are key enzymes in glucose metabolism) was dramatically lower in the experimental group. * compared to the control group (P < 0.05). # compared to the blank group (P < 0.05)

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Lipids in Health and Disease

ISSN: 1476-511X