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Table 4 Characterization of flurbiprofen loaded ethosomes

From: Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model

Characterization EF1 EF2 EF3 EF4 EF5 EF6 EF7 EF8 EF9
Vesicle Size (d.nm) 183.0 ± 3 179.2 ± 6 177.8 ± 5 173.8 ± 6 162.2 ± 2 191.0 ± 8 181. ± 9 190. ± 2 183.5 ± 1
% Entrapment efficiency 82 ± 2 85 ± 1% 83.5 ± 1 87 ± 1 92.1 ± 1 86.2 ± 2 88.2 ± 2 82.9 ± 2 90 ± 1
PDI 0.369 0.418 0.371 0.398 0.341 0.498 0.357 0.389 0.344
Zeta Potential (mV) −29.4 ± 0.5 −43.4 ± 1.8 −27.3 ± 2.3 −31 ± 2.4 −48.14 ± 1.4 −38.7 ± 3.1 − 34 ± 0.2 −29.3 ± 1.3 −35.1 ± 0.2
J (flux) (μg/cm2/h) 152.2 140.4 190.5 150.45 226.1 201.4 169.8 194.3 164.1
pH 6.6 5.4 6.1 6.3 5.2 5.4 6.4 5.1 5.1
Viscosity (cps) 7104 ± 0.6 6342 ± 1.4 7534 ± 2.43 7132 ± 3.12 8539 ± 1.1 7432 ± 1.3 6321 ± 1.8 7322 ± 2.1 6076 ± 1.2
Spreadability (cm) 4.1 ± 3.1 6.84 ± 0.3 7.22 ± 2.3 6.4 ± 0.5 7.12 ± 0.3 6.43 ± 0.5 6.54 ± 3.2 4.3 ± 3 3.2 ± 0.3