Table 4 Characterization of flurbiprofen loaded ethosomes

Vesicle Size (d.nm)

183.0 ± 3

179.2 ± 6

177.8 ± 5

173.8 ± 6

162.2 ± 2

191.0 ± 8

181. ± 9

190. ± 2

183.5 ± 1

% Entrapment efficiency

82 ± 2

85 ± 1%

83.5 ± 1

87 ± 1

92.1 ± 1

86.2 ± 2

88.2 ± 2

82.9 ± 2

90 ± 1

PDI

0.369

0.418

0.371

0.398

0.341

0.498

0.357

0.389

0.344

Zeta Potential (mV)

−29.4 ± 0.5

−43.4 ± 1.8

−27.3 ± 2.3

−31 ± 2.4

−48.14 ± 1.4

−38.7 ± 3.1

− 34 ± 0.2

−29.3 ± 1.3

−35.1 ± 0.2

J (flux) (μg/cm2/h)

152.2

140.4

190.5

150.45

226.1

201.4

169.8

194.3

164.1

pH

6.6

5.4

6.1

6.3

5.2

5.4

6.4

5.1

5.1

Viscosity (cps)

7104 ± 0.6

6342 ± 1.4

7534 ± 2.43

7132 ± 3.12

8539 ± 1.1

7432 ± 1.3

6321 ± 1.8

7322 ± 2.1

6076 ± 1.2

Spreadability (cm)

4.1 ± 3.1

6.84 ± 0.3

7.22 ± 2.3

6.4 ± 0.5

7.12 ± 0.3

6.43 ± 0.5

6.54 ± 3.2

4.3 ± 3

3.2 ± 0.3