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Table 5 Screening of analgesic activity of selected formulations using cold plate test in rats

From: Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model

S.No. Treatment Reaction time (sec.)
15 min 30 min 45 min 60 min
I Brugel Gel 16.9 ± 2.02 17.7 ± 2.4 19 ± 2.21 19.8 ± 2.41
II Etho 5 (10 mg/kg) 15.33 ± 0.51ns 16.8 ± 0.63ns 19.2 ± 0.63ns 21 ± 0.63ns
III Etho 5 (20 mg/kg) 15.66 ± 0.81ns 17.48 ± 0.5 ns 21.66 ± 0.51** 25.16 ± 0.40***
  1. ns Not significant
  2. **Significant
  3. ***Highly significant