Table 3 Effects of linolenic acid in vitro and in vivo clinical trials
From: The impact of sea buckthorn oil fatty acids on human health
Disorder | Study | Possible mechanism of action | References |
|---|---|---|---|
Cardiovascular risk | Human in vivo study | Ability to form EPA and DHA Reduction of plaque calcification Maintenance of endothelial function Reduction of blood pressure Exhibition of antithrombotic, anti arrhythmic and anti-inflammatory effects | Rajaram (2004) [26] Djoussé (2005) [27] Zhao (2004) [10] Takeuchi (2007) |
Dry eye | Human in vivo study | Attenuation of the increase in tear film osmolarity and possible influence over the intensity of burning and redness symptoms | Larmo (2010) [28] |
Fracture risk | Human in vivo study | Important role in bone turnover and maintenance of bone formation | Griel (2007) [29] Rajaram (2014) [26] García (2018) [30] |