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Table 1 Characteristics of the included studies

From: Prognostic value of lipid profiles after radical prostatectomy: a systematic review and meta-analysis

Study Year Country Design Size Operation Median Follow-Up (Month) Mean Age Statin Use Cofactors
Post 2011 USA Retrospective 383 RP 49 60.9 / Age, Race, Preoperative PSA, Gleason Score, Tumor Stage, Surgical Margin Status, Smoking, and Other Metabolic Syndrome Components
Allott 2014 USA Retrospective 843 RP 74.3 60.4 427 (50.7%) Age, Race, Pre-Operative PSA, Year of Surgery, BMI, Surgical Center, Statin Use, Pathological Gleason Score, Prostate Weight, Positive Surgical Margins, Extracapsular Extension, and Seminal Vesicle Invasion
Shiota 2014 Japan Prospective 283 Open (27.2%); LRP (14.8%); RALP (58.0%) 14.8 65 (49–78) a 48 (20.2%) Age, Pre-Operative PSA, Clinical T Stage, Pathological Stage, Biopsy Gleason Score, Surgical Approach, Surgical Margin, Pathological Gleason Score, Alteration of Gleason Score, Perineural Invasion, Angiolymphatic Invasion, Lymph Node Status
Jeannette 2015 Puerto Rico Retrospective 199 RP / 58.82 0 Age, BMI
Zhang 2015 China Retrospective 322 RP + PLD / 68 14 (4.3%) Age, BMI, Hypertension, Diabetes, Smoking Status, Statin Usage, Preoperative PSA, Biopsy Gleason Score, Clinical Stage
Kang 2015 China Retrospective 663 RP 21 68 (62–72) a / Biopsy Gleason Score, Pathological Gleason Score, Preoperative PSA, Pathological T Stage, Lymph Node Metastasis, Surgical Margin
Yoshio 2016 Japan Retrospective 562 Open (56.2%); RALP (43.8%) 54 65.9 69 (12.3%) Age, Pre-Operative PSA, BMI, Statin Use, Clinical T Stage, Gleason Score, Extracapsular Extension, Seminal Vesicle Invasion, Surgical Margin, Lympho-Vascular Invasion, Perineural Invasion, Lymph Node Metastases
Bhindi 2016 Canada Prospective 1939 Open (76%); LRP (6.1%); RALP (17.9%) 31 61.5 611 (31.5%) Age, Year Of RP, And Statin Use, Disease Parameters (PSA At Surgery, Final Grade, Pathological Stage, Surgical Margin Status), Surgical Approach of RP And Type of Nerve Sparing
Wettstein 2017 Switzerland Prospective 371 RP 28 63 61 (16.4%) Age, PSA, Extra-prostatic disease (> = pT3), High-risk disease (> = Gleason 8), Positive nodal status (pN1), Positive surgical margins, Statin use
Colicchia 2017 USA Prospective 3662 Open (69.4%); RALP (30.4%) 102 / / Age at Surgery, Total Number of Positive Cores, Max % Of Tumor in The Core, Clinical Stage, And Log 2 Pre-Surgery PSA.
Lebdai 2017 France Retrospective 567 Open (13.6%) LRP (6.2%); RALP (78.1%) / 64 (45–79) a / BMI, Abdominal Perimeter, Glycemia, High Blood Pressure
Rantaniemi 2018 Finland Retrospective 1314 RP 134.4 / 467 (35.5%) Age, Preoperative PSA Level, Pathological T Stage and Gleason Score, Use of Antihypertensive and Antidiabetic Medication, Non-Steroidal Anti-Inflammatory Drugs and Allopurinol, and Surgical Marginal Positivity
  1. RP radical prostatectomy, LRP laparoscopic radical prostatectomy, RALP robot-assisted radical prostatectomy, PLD pelvic lymphadenectomy, PSA prostate-specific antigen, BMI body mass index; /: data not available; a = median age