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Table 1 Dutch Lipid Clinic Network criteria for diagnosis of heterozygous familial hypercholesterolaemia in adults

From: Comparison of long-term outcomes of young patients after a coronary event associated with familial hypercholesterolemia

Criteria

Points

Family History

A First degree relative with known premature (< 55 years men; <  60 years women) coronary disease and vascular disease OR LDL-c > 95th percentile

1

B First degree relative with tendon xanthomata and/or arcuscornealis OR childhood (< 18 years) with LDL-c > 95th percentile

2

Clinical history

A Patient with premature CAD (men <55, women <60 years)

2

B Patient with premature cerebral or PVD (men <55, women <60 years)

1

Physical Examination

A Tendon xanthomas

6

B Premature arcus

4

biochemical results (LDL cholesterol)

A LDL – c >  8.5 mmol/L

8

B LDL-c 6.5–8.4 mmol/L

5

C LDL- c 5.0–6.4 mmol/L

3

D LDL – c 4.0–4.9 mmol/L

1

molecular genetic testing (DNA analysis)

DNA mutations

8

Definite FH: >  8 points, Probable FH: 6–8 points, Possible FH: 3–5