Skip to main content

Table 3 Clinical features, angiographic characteristics, and treatment of young patients after a coronary event with or without FH

From: Comparison of long-term outcomes of young patients after a coronary event associated with familial hypercholesterolemia

Variable

Total

FH statusa

 

Probable/Definite

(> 5 points)

Possible

(3–5 points)

None

(< 3 points)

P

Diagnosis

 STEMI, n(%)

468 (54.1)

16 (43.2)

126 (48.6)

326 (57.3)

0.027

 NONSTEMI, n(%)

75 (8.7)

0 (0.0)

29 (11.2)

46 (8.1)

0.054

 UAP, n(%)

314 (36.3)

21 (56.8)

101 (39.0)

192 (33.7)

0.010

 SAP, n(%)

8 (0.9)

0 (0.0)

3 (1.2)

5 (0.9)

0.774

Coronary angiography

 None, n(%)

100 (11.6)

1 (2.7)

33 (12.7)

66 (11.6)

0.216

 Single vessel, n(%)

448 (51.8)

8 (21.6)

131 (50.6)

309 (54.3)

0.001

 Double vessel, n(%)

195 (22.5)

13 (35.1)

57 (22.3)

125 (21.9)

0.173

 Triple vessel, n(%)

110 (12.7)

13 (35.1)

34 (13.1)

63 (11.1)

0.000

 Left main, n(%)

61 (7.1)

3 (8.1)

13 (5.0)

45 (7.9)

0.312

 CTO, n(%)

270 (31.2)

17 (45.9)

83 (32.2)

170 (29.9)

0.115

 Multivessel lesion, n (%)

317 (36.6)

28 (75.7)

95 (36.7)

194 (34.1)

0.000

 Gensini

32 (10–64)

50 (14–82)

32 (10–64)

32 (9–56)

0.008

Operation

 PCI, n(%)

539 (62.3)

20 (54.1)

176 (68.0)

343 (60.3)

0.061

 CABG, n(%)

90 (10.4)

12 (32.4)

17 (6.6)

61 (10.7)

0.000

 PTCA, n(%)

20 (2.3)

0 (0.0)

6 (2.3)

14 (2.5)

0.628

Medication at discharge

 Aspirin, n(%)

819 (94.7)

36 (97.3)

251 (96.9)

532 (93.5)

0.098

 β-blocker, n(%)

701 (81.0)

26 (70.3)

216 (83.4)

459 (80.7)

0.151

 ACEI/ARB, n(%)

472 (54.6)

13 (35.1)

146 (56.4)

313 (55.0)

0.049

 Statins, n(%)

719 (83.1)

28 (75.7)

226 (87.3)

465 (81.7)

0.067

 High-dose statins, n(%)

67 (7.7)

2 (5.4)

21 (8.1)

44 (7.7)

0.847

 Ezetimibe, n(%)

40 (4.6)

9 (24.3)

15 (5.8)

16 (2.8)

0.000

  1. FH familial hypercholesterolemia, pCAD premature coronary artery disease, STEMI ST-segment elevation myocardial infarction, NONSTEMI Non-ST-segment elevation myocardial infarction, UAP Unstable angina pectoris, SAP Stable angina pectoris, CTO chronic total occlusion, CABG coronary artery bypass grafting, PCI percutaneous coronary intervention, PTCA percutaneous transluminal coronary angioplast, ACEI/ARB angiotensin converting enzyme inhibitors/angiotensin receptor blocker
  2. aBased on Dutch Lipid Clinic Network criteria