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Table 4 Multivariable analysis of the association between FH and risk of MACCE

From: Comparison of long-term outcomes of young patients after a coronary event associated with familial hypercholesterolemia

FH statusa

Participants

(n)

MACCE

(n)

Incidence rate

(per 100 person-y)

Unadjusted

HR (95% CI)

Model 1

HR (95% CI)

Model 2

HR (95% CI)

No FH (Score < 3)

453

73

2.5

1.00 (Referent)

1.00 (Referent)

1.00 (Referent)

Possible FH (Score 3–5)

223

45

3.3

1.30 (0.89–1.88)

1.30 (0.90–1.89)

1.16 (0.77–1.75)

Probable/Definite FH

(Score > 5)

30

9

5.8

2.34 (1.17–4.68)

2.39 (1.19–4.78)

2.30 (1.09–4.84)

  1. FH familial hypercholesterolemia, MACCE major adverse cardiovascular and cerebrovascular events, HR hazard ratio, CI confidence interval. Model 1, adjusted for age and sex. Model 2, adjusted for age, sex and cardiovascular risk factors, including current smoking, hypertension, diabetes mellitus, and BMI
  2. aBased on Dutch Lipid Clinic Network criteria