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Table 4 Interaction of MTHFR C677T polymorphism with recurrent spontaneous abortion on serum folate and lipid levels

From: Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion

Variable Case control t p
CC genotype n = 213 n = 253   
 Folic acid, nmol/L 36.49 ± 6.47 35.29 ± 21.53 0.78 0.434
 Vitamin B12, pg/ml 347.23 ± 114.82 346.84 ± 124.51 0.03 0.976
 Homocysteine, umol/L 10.33 ± 4.34 10.83 ± 3.38 −1.39 0.165
 Total protein, g/L 72.87 ± 4.78 70.69 ± 9.99 2.93 0.004
 Total cholesterol, mmol/L 4.48 ± 1.09 4.51 ± 2.13 −0.16 0.873
 Triglyceride, mmol/L 1.06 ± 0.81 1.03 ± 0.57 0.68 0.494
 High-density lipoprotein cholesterol, mmol/L 1.68 ± 0.42 1.74 ± 0.36 −1.81 0.071
 Low-density lipoprotein cholesterol, mmol/L 2.65 ± 0.84 2.16 ± 0.60 1.78 0.082
 Fasting glucose, mmol/L 4.93 ± 0.38 4.92 ± 0.29 0.26 0.798
 Fasting insulin, pmol/L 70.64 ± 14.43 67.90 ± 14.03 2.08 0.038
 HOMR-IR 2.21 ± 0.45 2.12 ± 0.42 2.12 0.035
 IL6, pg/ml 81.84 ± 339.77 33.09 ± 215.37 1.89 0.058
 TNFα, pg/ml 29.11 ± 88.72 18.86 ± 30.27 1.75 0.081
CT genotype n = 153 n = 78   
 Folic acid, nmol/L 32.73 ± 7.85 38.43 ± 9.29 −3.55 0.000
 Vitamin B12, pg/ml 359.98 ± 131.88 353.94 ± 115.88 0.33 0.745
 Homocysteine, umol/L 12.65 ± 3.97 11.71 ± 3.06 1.99 0.047
 Total protein, g/L 71.68 ± 8.05 70.61 ± 8.01 0.92 0.361
 Total cholesterol, mmol/L 6.99 ± 32.56 4.17 ± 0.81 0.72 0.475
 Triglyceride, mmol/L 1.02 ± 0.52 0.95 ± 0.37 0.97 0.332
 High-density lipoprotein cholesterol, mmol/L 1.67 ± 0.33 1.72 ± 0.48 −0.92 0.358
 Low-density lipoprotein cholesterol, mmol/L 2.59 ± 0.78 2.39 ± 0.74 1.82 0.070
 Fasting glucose, mmol/L 4.95 ± 0.37 4.88 ± 0.39 0.62 0.532
 Fasting insulin, pmol/L 72.28 ± 15.42 66.89 ± 12.57 2.86 0.005
 HOMR-IR 2.27 ± 0.47 2.11 ± 0.36 2.83 0.005
 IL6, pg/ml 72.60 ± 275.52 41.08 ± 147.43 1.09 0.276
 TNFα, pg/ml 29.34 ± 106.30 16.52 ± 34.81 1.25 0.210
TT genotype n = 37 n = 11   
 Folic acid, nmol/L 25.72 ± 7.67 24.54 ± 7.84 0.45 0.658
 Vitamin B12, pg/ml 354.14 ± 142.24 322.82 ± 167.57 0.62 0.541
 Homocysteine, umol/L 17.80 ± 2.86 15.93 ± 2.08 2.39 0.026
 Total protein, g/L 70.17 ± 9.96 70.42 ± 3.79 −0.08 0.933
 Total cholesterol, mmol/L 4.34 ± 1.01 3.96 ± 0.80 1.13 0.265
 Triglyceride, mmol/L 1.11 ± 0.57 1.49 ± 0.73 −1.85 0.071
 High-density lipoprotein cholesterol, mmol/L 1.58 ± 0.33 1.62 ± 0.26 −0.31 0.761
 Low-density lipoprotein cholesterol, mmol/L 2.61 ± 0.76 2.43 ± 0.67 2.78 0.006
 Fasting glucose, mmol/L 4.95 ± 0.43 4.79 ± 0.36 1.38 0.175
 Fasting insulin, pmol/L 70.52 ± 16.13 67.86 ± 17.26 0.55 0.583
 HOMR-IR 2.21 ± 0.45 2.07 ± 0.54 0.96 0.341
 IL6, pg/ml 14.94 ± 43.01 104.44 ± 273.61 −1.58 0.126
 TNFα, pg/ml 15.72 ± 29.57 20.42 ± 19.78 −0.65 0.521
CT /TTgenotype n = 190 n = 89   
 Folic acid, nmol/L 31.31 ± 8.99 35.11 ± 21.36 −2.96 0.003
 Vitamin B12, pg/ml 358.84 ± 133.59 349.61 ± 123.50 0.53 0.598
 Homocysteine, umol/L 12.37 ± 4.57 11.52 ± 3.65 2.52 0.012
 Total protein, g/L 71.39 ± 8.45 70.59 ± 7.55 0.73 0.465
 Total cholesterol, mmol/L 6.48 ± 29.22 4.14 ± 0.81 0.71 0.478
 Triglyceride, mmol/L 1.04 ± 0.53 1.03 ± 0.47 0.14 0.887
 High-density lipoprotein cholesterol, mmol/L 1.66 ± 0.34 1.71 ± 0.45 −1.08 0.281
 Low-density lipoprotein cholesterol, mmol/L 2.61 ± 0.79 2.36 ± 0.72 2.38 0.018
 Fasting glucose, mmol/L 4.95 ± 0.38 4.94 ± 0.39 0.15 0.158
 Fasting insulin, pmol/L 71.99 ± 15.50 67.08 ± 13.55 2.78 0.006
 HOMR-IR 2.26 ± 0.47 2.11 ± 0.40 2.96 0.003
 IL6, pg/ml 63.25 ± 253.50 53.54 ± 119.70 0.37 0.714
 TNFα, pg/ml 15.72 ± 29.57 20.42 ± 19.78 −0.65 0.521
  1. HOMA-IR Homeostatic model assessment of insulin resistance, IL6 Interleukin 6, TNFα: Tumor necrosis factor α