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Table 4 Interaction of MTHFR C677T polymorphism with recurrent spontaneous abortion on serum folate and lipid levels

From: Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion

Variable

Case

control

t

p

CC genotype

n = 213

n = 253

  

 Folic acid, nmol/L

36.49 ± 6.47

35.29 ± 21.53

0.78

0.434

 Vitamin B12, pg/ml

347.23 ± 114.82

346.84 ± 124.51

0.03

0.976

 Homocysteine, umol/L

10.33 ± 4.34

10.83 ± 3.38

−1.39

0.165

 Total protein, g/L

72.87 ± 4.78

70.69 ± 9.99

2.93

0.004

 Total cholesterol, mmol/L

4.48 ± 1.09

4.51 ± 2.13

−0.16

0.873

 Triglyceride, mmol/L

1.06 ± 0.81

1.03 ± 0.57

0.68

0.494

 High-density lipoprotein cholesterol, mmol/L

1.68 ± 0.42

1.74 ± 0.36

−1.81

0.071

 Low-density lipoprotein cholesterol, mmol/L

2.65 ± 0.84

2.16 ± 0.60

1.78

0.082

 Fasting glucose, mmol/L

4.93 ± 0.38

4.92 ± 0.29

0.26

0.798

 Fasting insulin, pmol/L

70.64 ± 14.43

67.90 ± 14.03

2.08

0.038

 HOMR-IR

2.21 ± 0.45

2.12 ± 0.42

2.12

0.035

 IL6, pg/ml

81.84 ± 339.77

33.09 ± 215.37

1.89

0.058

 TNFα, pg/ml

29.11 ± 88.72

18.86 ± 30.27

1.75

0.081

CT genotype

n = 153

n = 78

  

 Folic acid, nmol/L

32.73 ± 7.85

38.43 ± 9.29

−3.55

0.000

 Vitamin B12, pg/ml

359.98 ± 131.88

353.94 ± 115.88

0.33

0.745

 Homocysteine, umol/L

12.65 ± 3.97

11.71 ± 3.06

1.99

0.047

 Total protein, g/L

71.68 ± 8.05

70.61 ± 8.01

0.92

0.361

 Total cholesterol, mmol/L

6.99 ± 32.56

4.17 ± 0.81

0.72

0.475

 Triglyceride, mmol/L

1.02 ± 0.52

0.95 ± 0.37

0.97

0.332

 High-density lipoprotein cholesterol, mmol/L

1.67 ± 0.33

1.72 ± 0.48

−0.92

0.358

 Low-density lipoprotein cholesterol, mmol/L

2.59 ± 0.78

2.39 ± 0.74

1.82

0.070

 Fasting glucose, mmol/L

4.95 ± 0.37

4.88 ± 0.39

0.62

0.532

 Fasting insulin, pmol/L

72.28 ± 15.42

66.89 ± 12.57

2.86

0.005

 HOMR-IR

2.27 ± 0.47

2.11 ± 0.36

2.83

0.005

 IL6, pg/ml

72.60 ± 275.52

41.08 ± 147.43

1.09

0.276

 TNFα, pg/ml

29.34 ± 106.30

16.52 ± 34.81

1.25

0.210

TT genotype

n = 37

n = 11

  

 Folic acid, nmol/L

25.72 ± 7.67

24.54 ± 7.84

0.45

0.658

 Vitamin B12, pg/ml

354.14 ± 142.24

322.82 ± 167.57

0.62

0.541

 Homocysteine, umol/L

17.80 ± 2.86

15.93 ± 2.08

2.39

0.026

 Total protein, g/L

70.17 ± 9.96

70.42 ± 3.79

−0.08

0.933

 Total cholesterol, mmol/L

4.34 ± 1.01

3.96 ± 0.80

1.13

0.265

 Triglyceride, mmol/L

1.11 ± 0.57

1.49 ± 0.73

−1.85

0.071

 High-density lipoprotein cholesterol, mmol/L

1.58 ± 0.33

1.62 ± 0.26

−0.31

0.761

 Low-density lipoprotein cholesterol, mmol/L

2.61 ± 0.76

2.43 ± 0.67

2.78

0.006

 Fasting glucose, mmol/L

4.95 ± 0.43

4.79 ± 0.36

1.38

0.175

 Fasting insulin, pmol/L

70.52 ± 16.13

67.86 ± 17.26

0.55

0.583

 HOMR-IR

2.21 ± 0.45

2.07 ± 0.54

0.96

0.341

 IL6, pg/ml

14.94 ± 43.01

104.44 ± 273.61

−1.58

0.126

 TNFα, pg/ml

15.72 ± 29.57

20.42 ± 19.78

−0.65

0.521

CT /TTgenotype

n = 190

n = 89

  

 Folic acid, nmol/L

31.31 ± 8.99

35.11 ± 21.36

−2.96

0.003

 Vitamin B12, pg/ml

358.84 ± 133.59

349.61 ± 123.50

0.53

0.598

 Homocysteine, umol/L

12.37 ± 4.57

11.52 ± 3.65

2.52

0.012

 Total protein, g/L

71.39 ± 8.45

70.59 ± 7.55

0.73

0.465

 Total cholesterol, mmol/L

6.48 ± 29.22

4.14 ± 0.81

0.71

0.478

 Triglyceride, mmol/L

1.04 ± 0.53

1.03 ± 0.47

0.14

0.887

 High-density lipoprotein cholesterol, mmol/L

1.66 ± 0.34

1.71 ± 0.45

−1.08

0.281

 Low-density lipoprotein cholesterol, mmol/L

2.61 ± 0.79

2.36 ± 0.72

2.38

0.018

 Fasting glucose, mmol/L

4.95 ± 0.38

4.94 ± 0.39

0.15

0.158

 Fasting insulin, pmol/L

71.99 ± 15.50

67.08 ± 13.55

2.78

0.006

 HOMR-IR

2.26 ± 0.47

2.11 ± 0.40

2.96

0.003

 IL6, pg/ml

63.25 ± 253.50

53.54 ± 119.70

0.37

0.714

 TNFα, pg/ml

15.72 ± 29.57

20.42 ± 19.78

−0.65

0.521

  1. HOMA-IR Homeostatic model assessment of insulin resistance, IL6 Interleukin 6, TNFα: Tumor necrosis factor α