Skip to main content

Table 5 Interaction of MTHFR A1298C polymorphism with recurrent spontaneous abortion on serum folate and lipid levels

From: Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion

Variable

Case

control

t

p

AA genotype

n = 231

n = 221

 

 Folic acid, nmol/L

31.28 ± 9.77

33.89 ± 23.08

−1.58

0.115

 Vitamin B12, pg/ml

352.21 ± 125.06

347.58 ± 124.71

0.39

0.694

 Homocysteine, umol/L

11.93 ± 4.63

11.27 ± 2.75

1.81

0.071

 Total protein, g/L

71.91 ± 7.99

70.26 ± 10.93

1.83

0.067

 Total cholesterol, mmol/L

4.32 ± 0.84

4.47 ± 2.08

−1.05

0.295

 Triglyceride, mmol/L

1.07 ± 0.77

1.06 ± 0.59

0.13

0.894

 High-density lipoprotein cholesterol, mmol/L

1.67 ± 0.39

1.76 ± 0.40

−2.51

0.012

 Low-density lipoprotein cholesterol, mmol/L

2.56 ± 0.74

2.45 ± 0.71

1.65

0.101

 Fasting glucose, mmol/L

4.92 ± 0.37

4.92 ± 0.38

0.02

0.987

 Fasting insulin, pmol/L

72.88 ± 14.93

67.83 ± 14.42

3.55

< 0.001

 HOMR-IR

2.28 ± 0.46

2.12 ± 0.43

3.74

< 0.001

 IL6, pg/ml

58.24 ± 239.93

36.23 ± 138.03

1.19

0.235

 TNFα, pg/ml

29.47 ± 108.57

19.73 ± 35.54

1.29

0.198

AC genotype

n = 144

n = 102

  

 Folic acid, nmol/L

34.18 ± 6.80

35.24 ± 6.50

−1.23

0.218

 Vitamin B12, pg/ml

354.39 ± 129.77

350.37 ± 116.89

0.25

0.804

 Homocysteine, umol/L

11.85 ± 4.63

11.06 ± 4.35

1.49

0.137

 Total protein, g/L

72.69 ± 4.52

71.63 ± 6.12

1.52

0.129

 Total cholesterol, mmol/L

7.41 ± 33.55

4.21 ± 1.23

0.96

0.337

 Triglyceride, mmol/L

1.07 ± 0.59

0.96 ± 0.44

1.54

0.126

 High-density lipoprotein cholesterol, mmol/L

1.65 ± 0.36

1.70 ± 0.35

−1.15

0.252

 Low-density lipoprotein cholesterol, mmol/L

2.73 ± 0.83

2.34 ± 0.65

3.88

0.000

 Fasting glucose, mmol/L

4.95 ± 0.39

4.94 ± 0.42

0.16

0.873

 Fasting insulin, pmol/L

68.94 ± 14.64

67.46 ± 13.49

0.03

0.409

 HOMR-IR

2.16 ± 0.43

2.11 ± 0.40

0.89

0.372

 IL6, pg/ml

109.82 ± 422.09

51.87 ± 305.40

1.26

0.208

 TNFα, pg/ml

28.91 ± 69.92

15.59 ± 21.63

2.16

0.032

CC genotype

n = 28

n = 19

  

 Folic acid, nmol/L

33.18 ± 9.09

34.99 ± 8.43

−0.69

0.494

 Vitamin B12, pg/ml

348.11 ± 80.49

330.79 ± 157.10

0.50

0.622

 Homocysteine, umol/L

12.43 ± 5.99

11.84 ± 4.58

0.36

0.717

 Total protein, g/L

71.67 ± 4.22

70.19 ± 4.62

1.14

0.262

 Total cholesterol, mmol/L

4.27 ± 0.74

4.93 ± 2.66

−1.23

0.226

 Triglyceride, mmol/L

0.89 ± 0.37

1.00 ± 0.49

−0.91

0.366

 High-density lipoprotein cholesterol, mmol/L

1.78 ± 0.42

1.62 ± 0.32

1.44

0.156

 Low-density lipoprotein cholesterol, mmol/L

2.41 ± 0.67

2.38 ± 0.53

0.16

0.876

 Fasting glucose, mmol/L

4.93 ± 0.38

5.00 ± 0.35

−0.81

0.420

 Fasting insulin, pmol/L

68.09 ± 13.33

66.68 ± 11.63

0.45

0.657

 HOMR-IR

2.14 ± 0.46

2.12 ± 0.36

0.24

0.809

 IL6, pg/ml

37.96 ± 81.36

30.61 ± 91.73

0.34

0.735

 TNFα, pg/ml

17.62 ± 22.33

18.33 ± 27.97

−0.11

0.910

AC /CCgenotype

n = 172

n = 121

  

 Folic acid, nmol/L

34.02 ± 7.20

35.20 ± 6.80

−1.42

0.155

 Vitamin B12, pg/ml

353.37 ± 122.93

347.30 ± 23.50

0.42

0.678

 Homocysteine, umol/L

11.86 ± 4.63

11.06 ± 4.35

1.49

0.137

 Total protein, g/L

72.52 ± 4.73

71.40 ± 5.92

1.80

0.073

 Total cholesterol, mmol/L

6.92 ± 30.79

4.32 ± 1.55

0.93

0.356

 Triglyceride, mmol/L

1.04 ± 0.57

0.96 ± 0.45

1.14

0.253

 High-density lipoprotein cholesterol, mmol/L

1.67 ± 0.37

1.68 ± 0.35

−0.42

0.672

 Low-density lipoprotein cholesterol, mmol/L

2.67 ± 0.81

2.35 ± 0.63

3.69

0.000

 Fasting glucose, mmol/L

4.94 ± 0.39

4.95 ± 0.40

−0.22

0.826

 Fasting insulin, pmol/L

68.79 ± 14.39

67.27 ± 13.02

0.98

0.325

 HOMR-IR

2.16 ± 0.43

2.11 ± 0.39

0.93

0.351

 IL6, pg/ml

97.57 ± 386.58

46.67 ± 269.04

1.37

0.170

 TNFα, pg/ml

26.98 ± 64.43

16.26 ± 23.26

2.04

0.042

  1. HOMA-IR Homeostatic model assessment of insulin resistance, IL6 Interleukin 6, TNFα Tumor necrosis factor α