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Table 5 Interaction of MTHFR A1298C polymorphism with recurrent spontaneous abortion on serum folate and lipid levels

From: Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion

Variable Case control t p
AA genotype n = 231 n = 221  
 Folic acid, nmol/L 31.28 ± 9.77 33.89 ± 23.08 −1.58 0.115
 Vitamin B12, pg/ml 352.21 ± 125.06 347.58 ± 124.71 0.39 0.694
 Homocysteine, umol/L 11.93 ± 4.63 11.27 ± 2.75 1.81 0.071
 Total protein, g/L 71.91 ± 7.99 70.26 ± 10.93 1.83 0.067
 Total cholesterol, mmol/L 4.32 ± 0.84 4.47 ± 2.08 −1.05 0.295
 Triglyceride, mmol/L 1.07 ± 0.77 1.06 ± 0.59 0.13 0.894
 High-density lipoprotein cholesterol, mmol/L 1.67 ± 0.39 1.76 ± 0.40 −2.51 0.012
 Low-density lipoprotein cholesterol, mmol/L 2.56 ± 0.74 2.45 ± 0.71 1.65 0.101
 Fasting glucose, mmol/L 4.92 ± 0.37 4.92 ± 0.38 0.02 0.987
 Fasting insulin, pmol/L 72.88 ± 14.93 67.83 ± 14.42 3.55 < 0.001
 HOMR-IR 2.28 ± 0.46 2.12 ± 0.43 3.74 < 0.001
 IL6, pg/ml 58.24 ± 239.93 36.23 ± 138.03 1.19 0.235
 TNFα, pg/ml 29.47 ± 108.57 19.73 ± 35.54 1.29 0.198
AC genotype n = 144 n = 102   
 Folic acid, nmol/L 34.18 ± 6.80 35.24 ± 6.50 −1.23 0.218
 Vitamin B12, pg/ml 354.39 ± 129.77 350.37 ± 116.89 0.25 0.804
 Homocysteine, umol/L 11.85 ± 4.63 11.06 ± 4.35 1.49 0.137
 Total protein, g/L 72.69 ± 4.52 71.63 ± 6.12 1.52 0.129
 Total cholesterol, mmol/L 7.41 ± 33.55 4.21 ± 1.23 0.96 0.337
 Triglyceride, mmol/L 1.07 ± 0.59 0.96 ± 0.44 1.54 0.126
 High-density lipoprotein cholesterol, mmol/L 1.65 ± 0.36 1.70 ± 0.35 −1.15 0.252
 Low-density lipoprotein cholesterol, mmol/L 2.73 ± 0.83 2.34 ± 0.65 3.88 0.000
 Fasting glucose, mmol/L 4.95 ± 0.39 4.94 ± 0.42 0.16 0.873
 Fasting insulin, pmol/L 68.94 ± 14.64 67.46 ± 13.49 0.03 0.409
 HOMR-IR 2.16 ± 0.43 2.11 ± 0.40 0.89 0.372
 IL6, pg/ml 109.82 ± 422.09 51.87 ± 305.40 1.26 0.208
 TNFα, pg/ml 28.91 ± 69.92 15.59 ± 21.63 2.16 0.032
CC genotype n = 28 n = 19   
 Folic acid, nmol/L 33.18 ± 9.09 34.99 ± 8.43 −0.69 0.494
 Vitamin B12, pg/ml 348.11 ± 80.49 330.79 ± 157.10 0.50 0.622
 Homocysteine, umol/L 12.43 ± 5.99 11.84 ± 4.58 0.36 0.717
 Total protein, g/L 71.67 ± 4.22 70.19 ± 4.62 1.14 0.262
 Total cholesterol, mmol/L 4.27 ± 0.74 4.93 ± 2.66 −1.23 0.226
 Triglyceride, mmol/L 0.89 ± 0.37 1.00 ± 0.49 −0.91 0.366
 High-density lipoprotein cholesterol, mmol/L 1.78 ± 0.42 1.62 ± 0.32 1.44 0.156
 Low-density lipoprotein cholesterol, mmol/L 2.41 ± 0.67 2.38 ± 0.53 0.16 0.876
 Fasting glucose, mmol/L 4.93 ± 0.38 5.00 ± 0.35 −0.81 0.420
 Fasting insulin, pmol/L 68.09 ± 13.33 66.68 ± 11.63 0.45 0.657
 HOMR-IR 2.14 ± 0.46 2.12 ± 0.36 0.24 0.809
 IL6, pg/ml 37.96 ± 81.36 30.61 ± 91.73 0.34 0.735
 TNFα, pg/ml 17.62 ± 22.33 18.33 ± 27.97 −0.11 0.910
AC /CCgenotype n = 172 n = 121   
 Folic acid, nmol/L 34.02 ± 7.20 35.20 ± 6.80 −1.42 0.155
 Vitamin B12, pg/ml 353.37 ± 122.93 347.30 ± 23.50 0.42 0.678
 Homocysteine, umol/L 11.86 ± 4.63 11.06 ± 4.35 1.49 0.137
 Total protein, g/L 72.52 ± 4.73 71.40 ± 5.92 1.80 0.073
 Total cholesterol, mmol/L 6.92 ± 30.79 4.32 ± 1.55 0.93 0.356
 Triglyceride, mmol/L 1.04 ± 0.57 0.96 ± 0.45 1.14 0.253
 High-density lipoprotein cholesterol, mmol/L 1.67 ± 0.37 1.68 ± 0.35 −0.42 0.672
 Low-density lipoprotein cholesterol, mmol/L 2.67 ± 0.81 2.35 ± 0.63 3.69 0.000
 Fasting glucose, mmol/L 4.94 ± 0.39 4.95 ± 0.40 −0.22 0.826
 Fasting insulin, pmol/L 68.79 ± 14.39 67.27 ± 13.02 0.98 0.325
 HOMR-IR 2.16 ± 0.43 2.11 ± 0.39 0.93 0.351
 IL6, pg/ml 97.57 ± 386.58 46.67 ± 269.04 1.37 0.170
 TNFα, pg/ml 26.98 ± 64.43 16.26 ± 23.26 2.04 0.042
  1. HOMA-IR Homeostatic model assessment of insulin resistance, IL6 Interleukin 6, TNFα Tumor necrosis factor α