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Table 6 Interaction of MTRR A66G polymorphism with recurrent spontaneous abortion on serum folate and lipid levels

From: Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion

Variable Case control t p
AA genotype n = 225 n = 226   
 Folic acid, nmol/L 33.20 ± 9.06 33.58 ± 8.42 −0.57 0.572
 Vitamin B12, pg/ml 362.49 ± 134.76 346.12 ± 126.65 1.33 0.185
 Homocysteine, umol/L 11.38 ± 4.59 11.05 ± 3.49 0.86 0.393
 Total protein, g/L 72.83 ± 5.21 71.08 ± 8.41 2.64 0.008
 Total cholesterol, mmol/L 6.27 ± 26.85 4.48 ± 2.25 0.99 0.320
 Triglyceride, mmol/L 1.17 ± 0.55 1.05 ± 0.56 1.75 0.081
 High-density lipoprotein cholesterol, mmol/L 1.68 ± 0.41 1.72 ± 0.39 −1.15 0.251
 Low-density lipoprotein cholesterol, mmol/L 2.67 ± 0.79 2.39 ± 0.72 3.97 0.000
 Fasting glucose, mmol/L 4.94 ± 0.39 4.92 ± 0.41 0.24 0.820
 Fasting insulin, pmol/L 71.08 ± 15.23 67.63 ± 14.54 2.20 0.028
 HOMR-IR 2.23 ± 0.47 2.11 ± 0.42 2.56 0.011
 IL6, pg/ml 67.27 ± 259.61 45.69 ± 255.26 0.79 0.426
 TNFα, pg/ml 26.26 ± 85.51 16.97 ± 22.95 1.47 0.143
AG genotype n = 148 n = 100   
 Folic acid, nmol/L 31.89 ± 9.38 33.84 ± 7.62 −1.86 0.064
 Vitamin B12, pg/ml 335.09 ± 107.21 340.27 ± 117.81 −0.36 0.720
 Homocysteine, umol/L 12.29 ± 4.31 11.29 ± 3.07 1.99 0.047
 Total protein, g/L 71.31 ± 7.81 69.38 ± 11.93 1.54 0.126
 Total cholesterol, mmol/L 4.31 ± 1.06 4.24 ± 0.68 0.58 0.561
 Triglyceride, mmol/L 0.93 ± 0.37 0.98 ± 0.52 −1.00 0.317
 High-density lipoprotein cholesterol, mmol/L 1.65 ± 0.33 1.77 ± 0.37 −2.60 0.010
 Low-density lipoprotein cholesterol, mmol/L 2.52 ± 0.73 2.45 ± 0.61 0.74 0.462
 Fasting glucose, mmol/L 4.94 ± 0.37 4.94 ± 0.38 −0.05 0.960
 Fasting insulin, pmol/L 71.43 ± 14.34 68.49 ± 13.09 1.84 0.067
 HOMR-IR 2.24 ± 0.43 2.16 ± 0.40 1.82 0.070
 IL6, pg/ml 102.91 ± 403.61 34.88 ± 120.71 2.02 0.044
 TNFα, pg/ml 28.02 ± 71.11 20.87 ± 40.68 1.08 0.281
GG genotype n = 30 n = 16   
 Folic acid, nmol/L 30.15 ± 9.40 48.46 ± 80.78 −1.24 0.222
 Vitamin B12, pg/ml 366.17 ± 110.06 411.75 ± 114.65 −1.32 0.194
 Homocysteine, umol/L 13.84 ± 5.66 12.71 ± 3.86 0.71 0.480
 Total protein, g/L 71.54 ± 10.64 72.81 ± 4.08 −0.46 0.649
 Total cholesterol, mmol/L 4.56 ± 1.46 4.69 ± 1.92 −0.27 0.792
 Triglyceride, mmol/L 0.87 ± 0.33 1.03 ± 0.56 −1.17 0.250
 High-density lipoprotein cholesterol, mmol/L 1.67 ± 0.36 1.69 ± 0.32 −0.22 0.828
 Low-density lipoprotein cholesterol, mmol/L 2.59 ± 0.87 2.48 ± 0.73 0.43 0.670
 Fasting glucose, mmol/L 4.87 ± 0.33 4.94 ± 0.31 −0.92 0.360
 Fasting insulin, pmol/L 70.39 ± 14.95 63.61 ± 12.91 2.19 0.032
 HOMR-IR 2.18 ± 0.46 2.00 ± 0.42 1.81 0.074
 IL6, pg/ml 18.62 ± 36.34 38.53 ± 180.82 −0.62 0.543
 TNFα, pg/ml 37.97 ± 155.97 14.07 ± 15.96 1.08 0.283
AG/GGgenotype n = 178 n = 116   
 Folic acid, nmol/L 31.59 ± 8.56 35.86 ± 30.44 −1.76 0.079
 Vitamin B12, pg/ml 340.33 ± 108.01 350.13 ± 119.48 −0.73 0.467
 Homocysteine, umol/L 12.55 ± 4.58 11.49 ± 3.21 2.18 0.030
 Total protein, g/L 71.34 ± 8.32 69.85 ± 11.24 1.31 0.193
 Total cholesterol, mmol/L 4.36 ± 1.14 4.31 ± 0.95 0.39 0.699
 Triglyceride, mmol/L 0.92 ± 0.36 0.98 ± 0.52 −1.38 0.108
 High-density lipoprotein cholesterol, mmol/L 1.65 ± 0.34 1.76 ± 0.37 −2.50 0.113
 Low-density lipoprotein cholesterol, mmol/L 2.52 ± 0.75 2.46 ± 0.62 0.87 0.383
 Fasting glucose, mmol/L 4.93 ± 0.36 4.94 ± 0.37 −0.48 0.640
 Fasting insulin, pmol/L 71.18 ± 14.46 67.56 ± 13.16 2.54 0.011
 HOMR-IR 2.23 ± 0.43 2.13 ± 0.41 2.34 0.020
 IL6, pg/ml 82.54 ± 353.49 35.57 ± 133.61 1.78 0.077
 TNFα, pg/ml 30.42 ± 98.18 19.58 ± 37.31 1.48 0.141
  1. HOMA-IR Homeostatic model assessment of insulin resistance, IL6 Interleukin 6, TNFα Tumor necrosis factor α