Table 6 Interaction of MTRR A66G polymorphism with recurrent spontaneous abortion on serum folate and lipid levels
Variable | Case | control | t | p |
|---|---|---|---|---|
AA genotype | n = 225 | n = 226 |  |  |
 Folic acid, nmol/L | 33.20 ± 9.06 | 33.58 ± 8.42 | −0.57 | 0.572 |
 Vitamin B12, pg/ml | 362.49 ± 134.76 | 346.12 ± 126.65 | 1.33 | 0.185 |
 Homocysteine, umol/L | 11.38 ± 4.59 | 11.05 ± 3.49 | 0.86 | 0.393 |
 Total protein, g/L | 72.83 ± 5.21 | 71.08 ± 8.41 | 2.64 | 0.008 |
 Total cholesterol, mmol/L | 6.27 ± 26.85 | 4.48 ± 2.25 | 0.99 | 0.320 |
 Triglyceride, mmol/L | 1.17 ± 0.55 | 1.05 ± 0.56 | 1.75 | 0.081 |
 High-density lipoprotein cholesterol, mmol/L | 1.68 ± 0.41 | 1.72 ± 0.39 | −1.15 | 0.251 |
 Low-density lipoprotein cholesterol, mmol/L | 2.67 ± 0.79 | 2.39 ± 0.72 | 3.97 | 0.000 |
 Fasting glucose, mmol/L | 4.94 ± 0.39 | 4.92 ± 0.41 | 0.24 | 0.820 |
 Fasting insulin, pmol/L | 71.08 ± 15.23 | 67.63 ± 14.54 | 2.20 | 0.028 |
 HOMR-IR | 2.23 ± 0.47 | 2.11 ± 0.42 | 2.56 | 0.011 |
 IL6, pg/ml | 67.27 ± 259.61 | 45.69 ± 255.26 | 0.79 | 0.426 |
 TNFα, pg/ml | 26.26 ± 85.51 | 16.97 ± 22.95 | 1.47 | 0.143 |
AG genotype | n = 148 | n = 100 |  |  |
 Folic acid, nmol/L | 31.89 ± 9.38 | 33.84 ± 7.62 | −1.86 | 0.064 |
 Vitamin B12, pg/ml | 335.09 ± 107.21 | 340.27 ± 117.81 | −0.36 | 0.720 |
 Homocysteine, umol/L | 12.29 ± 4.31 | 11.29 ± 3.07 | 1.99 | 0.047 |
 Total protein, g/L | 71.31 ± 7.81 | 69.38 ± 11.93 | 1.54 | 0.126 |
 Total cholesterol, mmol/L | 4.31 ± 1.06 | 4.24 ± 0.68 | 0.58 | 0.561 |
 Triglyceride, mmol/L | 0.93 ± 0.37 | 0.98 ± 0.52 | −1.00 | 0.317 |
 High-density lipoprotein cholesterol, mmol/L | 1.65 ± 0.33 | 1.77 ± 0.37 | −2.60 | 0.010 |
 Low-density lipoprotein cholesterol, mmol/L | 2.52 ± 0.73 | 2.45 ± 0.61 | 0.74 | 0.462 |
 Fasting glucose, mmol/L | 4.94 ± 0.37 | 4.94 ± 0.38 | −0.05 | 0.960 |
 Fasting insulin, pmol/L | 71.43 ± 14.34 | 68.49 ± 13.09 | 1.84 | 0.067 |
 HOMR-IR | 2.24 ± 0.43 | 2.16 ± 0.40 | 1.82 | 0.070 |
 IL6, pg/ml | 102.91 ± 403.61 | 34.88 ± 120.71 | 2.02 | 0.044 |
 TNFα, pg/ml | 28.02 ± 71.11 | 20.87 ± 40.68 | 1.08 | 0.281 |
GG genotype | n = 30 | n = 16 |  |  |
 Folic acid, nmol/L | 30.15 ± 9.40 | 48.46 ± 80.78 | −1.24 | 0.222 |
 Vitamin B12, pg/ml | 366.17 ± 110.06 | 411.75 ± 114.65 | −1.32 | 0.194 |
 Homocysteine, umol/L | 13.84 ± 5.66 | 12.71 ± 3.86 | 0.71 | 0.480 |
 Total protein, g/L | 71.54 ± 10.64 | 72.81 ± 4.08 | −0.46 | 0.649 |
 Total cholesterol, mmol/L | 4.56 ± 1.46 | 4.69 ± 1.92 | −0.27 | 0.792 |
 Triglyceride, mmol/L | 0.87 ± 0.33 | 1.03 ± 0.56 | −1.17 | 0.250 |
 High-density lipoprotein cholesterol, mmol/L | 1.67 ± 0.36 | 1.69 ± 0.32 | −0.22 | 0.828 |
 Low-density lipoprotein cholesterol, mmol/L | 2.59 ± 0.87 | 2.48 ± 0.73 | 0.43 | 0.670 |
 Fasting glucose, mmol/L | 4.87 ± 0.33 | 4.94 ± 0.31 | −0.92 | 0.360 |
 Fasting insulin, pmol/L | 70.39 ± 14.95 | 63.61 ± 12.91 | 2.19 | 0.032 |
 HOMR-IR | 2.18 ± 0.46 | 2.00 ± 0.42 | 1.81 | 0.074 |
 IL6, pg/ml | 18.62 ± 36.34 | 38.53 ± 180.82 | −0.62 | 0.543 |
 TNFα, pg/ml | 37.97 ± 155.97 | 14.07 ± 15.96 | 1.08 | 0.283 |
AG/GGgenotype | n = 178 | n = 116 |  |  |
 Folic acid, nmol/L | 31.59 ± 8.56 | 35.86 ± 30.44 | −1.76 | 0.079 |
 Vitamin B12, pg/ml | 340.33 ± 108.01 | 350.13 ± 119.48 | −0.73 | 0.467 |
 Homocysteine, umol/L | 12.55 ± 4.58 | 11.49 ± 3.21 | 2.18 | 0.030 |
 Total protein, g/L | 71.34 ± 8.32 | 69.85 ± 11.24 | 1.31 | 0.193 |
 Total cholesterol, mmol/L | 4.36 ± 1.14 | 4.31 ± 0.95 | 0.39 | 0.699 |
 Triglyceride, mmol/L | 0.92 ± 0.36 | 0.98 ± 0.52 | −1.38 | 0.108 |
 High-density lipoprotein cholesterol, mmol/L | 1.65 ± 0.34 | 1.76 ± 0.37 | −2.50 | 0.113 |
 Low-density lipoprotein cholesterol, mmol/L | 2.52 ± 0.75 | 2.46 ± 0.62 | 0.87 | 0.383 |
 Fasting glucose, mmol/L | 4.93 ± 0.36 | 4.94 ± 0.37 | −0.48 | 0.640 |
 Fasting insulin, pmol/L | 71.18 ± 14.46 | 67.56 ± 13.16 | 2.54 | 0.011 |
 HOMR-IR | 2.23 ± 0.43 | 2.13 ± 0.41 | 2.34 | 0.020 |
 IL6, pg/ml | 82.54 ± 353.49 | 35.57 ± 133.61 | 1.78 | 0.077 |
 TNFα, pg/ml | 30.42 ± 98.18 | 19.58 ± 37.31 | 1.48 | 0.141 |