Study, year | Group: dose(n) | Hypoglycemia (FPG < 60 mg/dL) (n) | Gastrointestinal disorder (n) | Upper respiratory tract infection (n) | ALT > 3 times ULN (n) | Vomiting(n) | Nausea(n) | Diarrhea(n) |
---|---|---|---|---|---|---|---|---|
Derosa, 2012a [20] | sita:100 mg + met:2500 mg(91) | 0 | 1 | NS | NS | 2 | 0 | 3 |
met:2500 mg(87) | 0 | 2 | NS | NS | 1 | 1 | 0 | |
Asahara, 2013 [21] | sita:50 mg(24) | NS | NS | NS | NS | NS | NS | NS |
pla:50 mg(24) | NS | NS | NS | NS | NS | NS | NS | |
Suzuki, 2014 [22] | sita:50 mg(16) | NS | NS | NS | NS | NS | NS | NS |
lira:0.9 mg(24) | NS | NS | NS | NS | NS | NS | NS | |
Liu, 2013 [23] | sita:100 mg(60) | 5 | 12 | NS | 1 | NS | NS | NS |
piog:30 mg(60) | 6 | 4 | NS | 0 | NS | NS | NS | |
Derosa, 2010 [24] | sita:100 mg + piog:30 mg(75) | 2 | 0 | NS | NS | 1 | 0 | 1 |
met:850 mg + piog:30 mg(76) | 0 | 3 | NS | NS | 1 | 2 | 1 | |
Nakamura, 2014 [25] | sita:50 mg(24) | 0 | NS | NS | NS | NS | 0 | 0 |
vog:0.6 mg(31) | NS | NS | NS | NS | NS | 1 | 1 | |
Derosa, 2012b [26] | vild:100 mg + met:2500 ± 500 mg(84) | 0 | 0 | NS | NS | 2 | 2 | 0 |
Pla + met:2500 ± 500 mg(83) | 0 | 2 | NS | NS | 0 | 0 | 3 | |
Strozik, 2014a [27] | vild:100 mg + met:1500 mg(15) | 0 | 3 | NS | NS | NS | NS | NS |
met:1500 mg(13) | 0 | 0 | NS | NS | NS | NS | NS | |
Zografou, 2015 [28] | vild:50 mg + met:850 mg(32) | NS | NS | 0 | NS | NS | NS | NS |
met: 850 mg(32) | NS | NS | 1 | NS | NS | NS | NS | |
Derosa, 2014 [29] | vild:100 mg(86) | 0 | NS | NS | NS | NS | NS | NS |
glim:6 mg(70) | 8 | NS | NS | NS | NS | NS | NS | |
Kim, 2017 [30] | vild:50 mg(14) | NS | NS | NS | NS | NS | NS | NS |
piog:15 mg(11) | NS | NS | NS | NS | NS | NS | NS | |
Mita, 2015 [31] | alo:25 mg(172) | 5 | NS | NS | NS | NS | NS | NS |
con(169) | 6 | NS | NS | NS | NS | NS | NS | |
Boer, 2017 [32] | lin:5 mg(22) | NS | NS | NS | 1 | NS | NS | NS |
pla(22) | NS | NS | NS | 0 | NS | NS | NS | |
Yamada, 2017 [33] | sig:50 mg(55) | NS | NS | NS | NS | NS | NS | NS |
con(60) | NS | NS | NS | NS | NS | NS | NS | |
Koren, 2012 [34] | sita:100 mg(20) | 1 | NS | NS | NS | NS | NS | NS |
glib:5 mg(20) | 14 | |||||||
Nogueira, 2014 [35] | sita:100 mg(18) | NS | NS | NS | NS | NS | NS | NS |
insu:11 ± 6.7(17) |