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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1

Fig. 2

Quantitative RT-PCR of S1pr (Sphingosine-1-phosphate receptor) 1–5 in spleen tissue of sham- and treated Npc1+/+ (sham, n = 3; treated, n = 3) and Npc1−/− (sham, n = 3; treated, n = 3) mice. Sham-treated Npc1−/− mice demonstrated a noticeable increase of S1pr2 and S1pr4. The expression tended to be normalized after treatment. Data are normalized to Ppia and shown as mean ± SEM. p ≤ 0.05 was considered significant (*p ≤ 0.05). For p-values see text. S1pr: Sphingosine-1-phosphat receptor, Ppia: Peptidylprolyl isomerase A

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