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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1

Fig. 3

HPTLC-analysis (a) and mass spectroscopy (b) of spleen tissue of sham-treated and treated Npc1+/+ (sham, n = 3, treated, n = 3) mice. (b) Sham-treated Npc1+/+ and treated Npc1+/+ were set to 100%. Notice the band differences of sham-treated Npc1−/− and the approximation to treated Npc1+/+ and Npc1−/−. Sham-treated Npc1−/− showed a significant increase of SM, S1P, Sph, Dh-Sph, LPC, C16-Cer and PC. The treatment normalized the lipid levels. All data represent the mean ± SEM. p ≤ 0.05 was considered significant (*p ≤ 0.05). For p-values see text. SM: Sphingomyeline, S1P: Sphingosine-1-Phosphate, Sph: Sphingosine, DH-Sph: Dihydro-Sphingosine, C16-Cer: C16-Ceramide, LPC: Lysophosphatidylcholine, PC: Phosphatidylcholine

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