Fig. 4

Hematoxylin & Eosin-stained images of spleen tissue of a sham-treated and treated Npc1^+/+ (a, e and high magnification a, f) and of a sham-treated and treated Npc1^−/− mouse (c, g and high magnification d, h). Note the foam cells in the spleen tissue of a sham-treated Npc1^−/− mouse (c, d), and the amelioration in the spleen tissue of treated Npc1^−/− mouse (g, h). A scale bar is shown in g, which also applies to a,c,e: 100 μm and in h, also applies to b,d,f: 50 μm