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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1

Fig. 5

Paraffin sections from the spleen of sham-treated and treated Npc1+/+ and Npc1−/ mice were immunhistochemically analyed with the macrophage markers CD68 (a, c, e, g) and Iba1 (b, d, f, h). The brown areas are positive reactions stained by DAB, counter stained with hematoxylin. Increased reaction of CD68 and Iba1 in sham-treated Npc1−/− (c, d). The reaction of Iba1 is reduced in treated Npc1−/− mouse (h). Scale bar: H: 50 μm and also applies to a-g

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