Fig. 6

Quantitative analysis of leukocytes (n = 3) in spleen of sham-treated Npc1^+/+ and Npc1^−/− mice as well as treated Npc1^+/+ and treated Npc1^−/− mice. Sham-treated Npc1^−/− demonstrated significant accumulation of myeloid cells and slight changes of T cells and DCs. Treated Npc1^−/− showed a reduction of CTLs, myeloid cells and the rise of ratio Th to CTL cells. Note also the different changes of Th cells, CTLs and ratio between sham-treated Npc1^+/+ and treated Npc1^−/−. All data represent the mean ± SEM. p ≤ 0.05 was considered significant (*p ≤ 0.05). For p-values see text. Th: T helper cells, CTLs: Cytotoxic T lymphocytes, DCs: Dendritic cells