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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1

Fig. 6

Quantitative analysis of leukocytes (n = 3) in spleen of sham-treated Npc1+/+ and Npc1−/− mice as well as treated Npc1+/+ and treated Npc1−/− mice. Sham-treated Npc1−/ demonstrated significant accumulation of myeloid cells and slight changes of T cells and DCs. Treated Npc1−/− showed a reduction of CTLs, myeloid cells and the rise of ratio Th to CTL cells. Note also the different changes of Th cells, CTLs and ratio between sham-treated Npc1+/+ and treated Npc1−/−. All data represent the mean ± SEM. p ≤ 0.05 was considered significant (*p ≤ 0.05). For p-values see text. Th: T helper cells, CTLs: Cytotoxic T lymphocytes, DCs: Dendritic cells

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