Lipids in Health and Disease

Table 3 Regression analyses of age- and sex-adjusted ∆apoB-containing lipoproteins vs. ∆BMI over clinic visits, SI units

From: Effects of weight change on apolipoprotein B-containing emerging atherosclerotic cardiovascular disease (ASCVD) risk factors

	Adjusted for age and sex only		Additional adjustment for ∆triglycerides and ∆LDL-cholesterol		Sample (N)
Dependent variable	Slope ± SE	Significance	Slope ± SE	Significance
∆Apo B^b
1st followup	0.0064 ± 0.0007	< 10^− 16	0.001 ± 0.0003	0.0008	29342
2nd followup	0.0063 ± 0.0011	1.9 × 10⁻⁸	0.0016 ± 0.0005	0.0006	9642
3rd followup	0.007 ± 0.0017	5.8 × 10⁻⁵	0.001 ± 0.0007	0.16	3877
∆nonHDL-cholesterol ^a
1st followup	0.0289 ± 0.0027	< 10⁻¹⁶	0.0019 ± 0.0009	0.03	27613
2nd followup	0.027 ± 0.0045	1.5 × 10⁻⁹	0.0058 ± 0.0015	0.0001	9180
3rd followup	0.0252 ± 0.0063	6.8 × 10⁻⁵	0.0088 ± 0.0022	6.3 × 10^− 5	3952
∆sdLDL-cholesterol ^a
1st followup	0.0008 ± 0.0001	< 10⁻¹⁶	0.0001 ± 0.0000	1.6 × 10⁻¹¹	29988
2nd followup	0.0007 ± 0.0001	< 10⁻¹⁶	0.0002 ± 0.0001	1.5 × 10⁻¹¹	10164
3rd followup	0.0006 ± 0.0002	6.6 × 10⁻⁹	0.0002 ± 0.0001	0.0003	4396
∆lbLDL-cholesterol ^a
1st followup	0.0059 ± 0.0018	0.0009	−0.0041 ± 0.0006	3.4 × 10⁻¹³	30056
2nd followup	0.0029 ± 0.0029	0.33	−0.0059 ± 0.0009	3.8 × 10⁻¹¹	10124
3rd followup	0.0073 ± 0.0041	0.08	−0.0052 ± 0.0012	3.2 × 10⁻¹⁵	4376
∆%sdLDL-cholesterol^c
1st followup	0.254 ± 0.02	< 10⁻¹⁶	0.151 ± 0.018	< 10⁻¹⁶	24274
2nd followup	0.274 ± 0.034	4.4 × 10⁻¹⁶	0.186 ± 0.03	3.8 × 10⁻¹⁰	7633
3rd followup	0.27 ± 0.053	2.9 × 10⁻⁷	0.218 ± 0.049	8.2 × 10⁻⁶	2952
∆LDL-particle number^a
1st followup	0.0121 ± 0.0017	2.9 × 10⁻¹³	0.0032 ± 0.0010	0.001	16135
2nd followup	0.0105 ± 0.0025	2.6 × 10⁻⁵	0.0039 ± 0.0015	0.01	5554
3rd followup	0.0119 ± 0.0033	0.0003	0.0037 ± 0.0022	0.10	2452
∆Lp(a)^d
1st followup	−0.0059 ± 0.0021	0.005	−0.0091 ± 0.0021	1.2 × 10⁻⁵	28096
2nd followup	−0.0163 ± 0.0033	7.8 × 10⁻⁷	− 0.018 ± 0.0033	5.3 × 10⁻⁸	9673
3rd followup	−0.0142 ± 0.0045	0.002	−0.0155 ± 0.0045	0.0006	4264
∆Log Lp(a)
1st followup	−0.001 ± 0	0.005	−0.002 ± 0	9.0 × 10⁻⁶	28096
2nd followup	−0.003 ± 0.001	2.9 × 10^− 6	−0.003 ± 0.001	2.2 × 10⁻⁷	9673
3rd followup	−0.003 ± 0.001	0.002	−0.003 ± 0.001	0.0006	4264
∆Triglycerides^a
1st followup	0.0328 ± 0.0027	< 10⁻¹⁶			32674
2nd followup	0.032 ± 0.0045	7.5 × 10⁻¹³			11001
3rd followup	0.0241 ± 0.006	6.1 × 10⁻⁵			4706
∆LDL-cholesterol^a
1st followup	0.0186 ± 0.0023	6.7 × 10⁻¹⁶			31981
2nd followup	0.0155 ± 0.0038	5.3 × 10⁻⁵			10776
3rd followup	0.019 ± 0.0054	0.0004			4618

^a ∆mmol/L per ∆kg/m²; ^b ∆g/L per ∆kg/m²; ^c∆% per ∆kg/m²; ^d∆μmol/L per ∆kg/m²

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