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Table 5 Statin persistence over time according to age strata at baseline

From: Long-term statin persistence is poor among high-risk patients with dyslipidemia: a real-world administrative claims analysis

Cohort

 

Time (Years)

0.5

1

2

3

4

5

  

A) Elevated-TG analysis

Study population with age category 45–54 (1)

Proportion

0.5244

0.3851

0.2615

0.2024

0.1643

0.1353

  

At risk

2819

1770

936

603

363

219

  

Study population with age category 55–64 (2)

Proportion

0.6025

0.4673

0.3377

0.2636

0.2118

0.1794

  

At risk

5661

3756

2028

1263

700

443

  

Study population with age category 65+ (3)

Proportion

0.6596

0.5308

0.3898

0.3144

0.2655

0.2295

  

At risk

5479

3746

2299

1582

971

709

  

Comparison group with age category 45–54 (4)

Proportion

0.5011

0.3824

0.2674

0.2028

0.1559

0.1310

  

At risk

2678

1756

971

624

341

237

  

Comparison group with age category 55–64 (5)

Proportion

0.6108

0.4803

0.3496

0.2814

0.2317

0.1982

  

At risk

5708

3901

2135

1350

761

492

  

Comparison group with age category 65+ (6)

Proportion

0.6454

0.5201

0.3867

0.3137

0.2651

0.2274

  

At risk

5410

3739

2308

1663

1016

706

  

Clustered P values for between-group comparisons in the elevated-TG analysis

 

1 vs 2

1 vs 3

1 vs 4

1 vs 5

1 vs 6

2 vs 3

2 vs 4

2 vs 5

 

<0.001

<0.001

0.494

<0.001

<0.001

<0.001

<0.001

0.016

 

2 vs 6

3 vs 4

3 vs 5

3 vs 6

4 vs 5

4 vs 6

5 vs 6

 
  

<0.001

<0.001

<0.001

0.312

<0.001

<0.001

<0.001

 

B) High-TG analysis

Study population with age category 45–54 (1)

Proportion

0.5138

0.3693

0.2530

0.1883

0.1499

0.1243

  

At risk

1394

857

462

282

161

102

  

Study population with age category 55–64 (2)

Proportion

0.5844

0.4492

0.3170

0.2521

0.1987

0.1686

  

At risk

2624

1726

914

590

325

204

  

Study population with age category 65+ (3)

Proportion

0.6546

0.5281

0.3827

0.3048

0.2498

0.2143

  

At risk

2447

1658

995

673

413

299

  

Comparison group with age category 45–54 (4)

Proportion

0.4846

0.3701

0.2648

0.2055

0.1620

0.1360

  

At risk

1300

850

484

315

176

117

  

Comparison group with age category 55–64 (5)

Proportion

0.6024

0.4661

0.3322

0.2686

0.2249

0.1965

  

At risk

2679

1794

970

611

347

221

  

Comparison group with age category 65+ (6)

Proportion

0.6416

0.5148

0.3816

0.3089

0.2638

0.2280

  

At risk

2449

1684

1020

731

450

312

  

Clustered P values for between-group comparisons in the high-TG analysis

 

1 vs 2

1 vs 3

1 vs 4

1 vs 5

1 vs 6

2 vs 3

2 vs 4

2 vs 5

 

<0.001

<0.001

0.849

<0.001

<0.001

<0.001

<0.001

0.019

 

2 vs 6

3 vs 4

3 vs 5

3 vs 6

4 vs 5

4 vs 6

5 vs 6

 
 

<0.001

<0.001

<0.001

0.838

<0.001

<0.001

<0.001

 
  1. Kaplan-Meier analysis. Clustered P values were calculated using Cox proportional hazard model with cohort as independent variable. Study population is the elevated-TG cohort (TG ≥150 mg/dL) and high-TG subcohort and their propensity score matched comparators with TG < 150 mg/dL and HDL-C > 40 mg/dL
  2. HDL-C high-density lipoprotein cholesterol, TG triglycerides
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Lipids in Health and Disease

ISSN: 1476-511X