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Table 3 Associations of VDR SNP genotypes and metabolic and anthropometric measures in response to vitamin D3 supplementation (4000 IU/day) in breast cancer survivors using multivariate multiple regression

From: Vitamin D receptor gene polymorphisms affecting changes in visceral fat, waist circumference and lipid profile in breast cancer survivors supplemented with vitamin D3

Changes in varibles APa1, β (95% CI) TaqI, β (95% CI) BsmI, β (95% CI) FokI, β (95% CI) Cdx2, β (95% CI)
Aa
(n = 52)
aa
(n = 18)
Tt
(n = 67)
tt
(n = 14)
Bb
(n = 65)
bb
(n = 16)
Ff
(n = 66)
ff
(n = 17)
GA
(n = 52)
AA
(n = 14)
BMI, Kg/m2
P value
0.13
(−0.17,0,44)
0.39
0.21
(− 0.23, 0.66)
0.35
− 0.06
(− 0.37,.24)
0.66
0.03
(− 0.45,0.53)
0.87
0.08
(− 0.21,0.38)
0.58
0.06
(− 0.41,0.54)
0.78
0.01
(− 0.27,0.31)
0.90
− 0.2
(− 0.6,0.2)
0.37
−0.16
(− 0.46. 0.14)
0.29
0
(− 0.48,0.50)
0.96
WC, cm
P value
−0.4
(−3.3, 2.3)
0.72
0.8
(−3.2,4.8)
0.69
−1.4
(−4.1,1.3)
0.31
− 1.3
(−5.7,3.1)
0.55
2.7
(0.1,5.3)
0.04
3.9
(− 0.2,8.1)
0.06
1.2
(− 1.3,3.9)
0.34
−0.8
(− 4.9,3.2)
0.68
1.8
(− 0.8,4.6)
0.17
−1.2
(− 5.6, 3.2)
0.59
HC, cm
P value
0.9
(− 1.1,3.0)
0.37
0.9
(−2.0,4.0)
0.53
1.9
(− 0.1,3.9)
0.06
0.6
(− 2.6,3.9)
0.70
0.9
(− 1.0,2.9)
0.32
0.1
(− 3.0, 3.3)
0.93
1.4
(− 0.5,3.3)
0.15
0.1
(− 2.9, 3.1)
0.93
−0.8
(− 2.9,1.1)
0.41
0.17
(− 3.1,3.5)
0.91
Fat mass (%)
P value
0.08
(− 0.70,0.86)
0.83
0.53
(− 0.59,1.66)
0.34
−0.1
(− 0.9,0.6)
0.70
−0.2
(− 1.5,0.9)
0.66
0.2
(− 0.5, 1.0)
0.53
0.5
(− 0.6,1.8)
0.3
0.4
(− 0.3,1.1)
0.28
−0.8
(− 2.0,0.3)
0.14
0.06
(− 0.74,0.87)
0.86
−0.2
(− 1.5, 1.1)
0.75
Muscle mass (%)
P value
0.2
(−41.9,42.3)
0.99
71.3
(10.7131.9)
0.02
− 22.0
(− 63.9,19.8)
0.30
− 25.7
(− 93.3,41.8)
0.45
− 22.4
(− 62.1,17.3)
0.26
− 26.7
(− 90.6,37.2)
0.41
19.7
(− 19.9,59.4)
0.32
1.7
(− 59.7,63.2)
0.95
20.3
(− 20.6,61.3)
0.32
− 6.8
(− 73.8,60.1)
0.84
Trunk fat (%)
P value
0. 2
(− 0.8,1.3)
0.67
0.5
(− 1.0,2.1)
0.65
− 0.06
(− 1.15, 1.02)
0.90
−0.1
(− 1.9, 1.5)
0.84
0.3
(− 0.7,1.4)
0.58
0.7
(− 0.9,2.5)
0.38
0.5
(− 0.5,1.6)
0.34
− 1.0
(− 2.7,0.6)
0.22
0.2
(− 0.9,1.3)
0.71
− 0.2
(− 2.1,1.5)
0.77
Visceral fat
P value
0.1
(− 0.2,0.4)
0.5
0.2
(− 0.2,0.7)
0.37
− 0.1
(− 0.4,0.2)
−0.1
(− 0.7,0.3)
− 0.04
(− 0.37,0.27)
0.77
0.3
(− 0.1,0 .8)
0.17
0.1
(− 0.1,0.4)
0.32
−0.2
(− 0.7,0.2)
0.38
−0.03
(− 0.3,0.3)
0.82
−0.04
(− 0.6,0.5)
0.86
LDL, mg/dL
P value
− 4.0
(− 15.0,6.8)
0.46
− 17.9
(− 33.6, − 2.3)
0.02
0.6
(− 10.1,11.3)
0.90
7.4
(− 10.0,24.9)
0.40
3.9
(− 6.3,14.2)
0.44
2.1
(− 14.5,18.8)
0.79
3.2
(− 7.0,13.5)
0.53
−2.5
(− 18.5,13.5)
0.75
−6.5
(− 16.9,3.8)
0.21
− 18.1
(− 35.3, − 0.9)
0.03
HDL, mg/dL
P value
0.9
(− 3.5,5.4)
0.68
2.3
(− 4.0,8.8)
0.46
−2.2
(− 6.5,2.06)
0.30
0.84
(− 6.1,7.8)
0.81
− 1.8
(− 5.9,2.3)
0.38
3.3
(− 3.2,10.0)
0.31
1.4
(−2.6.5.5)
0.48
− 0.6
(− 7.10,5.7)
0.83
− 0.7
(− 5.0, 3.4)
0.72
1.2
(− 5.7, 8.2)
0.72
TC, mg/dL
P value
−4.1
(− 18.9,10.7)
0.58
−4.8
(− 26.0,16.3)
0.65
−9.7
(− 23.9,4.4)
0.17
3.7
(− 19.3,26.7)
0.75
3.8
(− 10.1,17.9)
0.58
11.4
(− 11.3,34.2)
0.32
−1.2
(− 15.3,12.7)
0.85
−3.8
(− 25.7,18.0)
0.72
−9.8
(− 24.1, 4.4)
0.17
−22.1
(− 45.7, 1.3)
0.06
TG, mg/dL
P value
6.3
(− 14.1,26.8)
0.54
− 13.1
(− 42.4,16.2)
0.37
2.5
(− 17.3,22.4)
0.79
21.2
(− 11.0,53.6)
0.19
8.6
(− 10.4, 27.7)
0.37
−4.5
(− 35.4, 26.3)
0.77
−9.4
(− 28.4,9.5)
0.32
6.2
(− 23.3,35.8)
0.67
− 3.0
(− 22.6,16.4)
0.75
−25.9
(− 58.1, 6.2)
0.11
  1. BMI Body mass index, WC Waist circumference, HC Hip circumference, TC Total cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, TG Triglycerides
  2. All values were adjusted for age, baseline 25-hydroxy vitamin D (25(OH)D), energy intake, fat intake and physical activity