Table 3 Associations of VDR SNP genotypes and metabolic and anthropometric measures in response to vitamin D3 supplementation (4000 IU/day) in breast cancer survivors using multivariate multiple regression
Changes in varibles | APa1, β (95% CI) | TaqI, β (95% CI) | BsmI, β (95% CI) | FokI, β (95% CI) | Cdx2, β (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Aa (n = 52) | aa (n = 18) | Tt (n = 67) | tt (n = 14) | Bb (n = 65) | bb (n = 16) | Ff (n = 66) | ff (n = 17) | GA (n = 52) | AA (n = 14) | |
BMI, Kg/m2 P value | 0.13 (−0.17,0,44) 0.39 | 0.21 (− 0.23, 0.66) 0.35 | − 0.06 (− 0.37,.24) 0.66 | 0.03 (− 0.45,0.53) 0.87 | 0.08 (− 0.21,0.38) 0.58 | 0.06 (− 0.41,0.54) 0.78 | 0.01 (− 0.27,0.31) 0.90 | − 0.2 (− 0.6,0.2) 0.37 | −0.16 (− 0.46. 0.14) 0.29 | 0 (− 0.48,0.50) 0.96 |
WC, cm P value | −0.4 (−3.3, 2.3) 0.72 | 0.8 (−3.2,4.8) 0.69 | −1.4 (−4.1,1.3) 0.31 | − 1.3 (−5.7,3.1) 0.55 | 2.7 (0.1,5.3) 0.04 | 3.9 (− 0.2,8.1) 0.06 | 1.2 (− 1.3,3.9) 0.34 | −0.8 (− 4.9,3.2) 0.68 | 1.8 (− 0.8,4.6) 0.17 | −1.2 (− 5.6, 3.2) 0.59 |
HC, cm P value | 0.9 (− 1.1,3.0) 0.37 | 0.9 (−2.0,4.0) 0.53 | 1.9 (− 0.1,3.9) 0.06 | 0.6 (− 2.6,3.9) 0.70 | 0.9 (− 1.0,2.9) 0.32 | 0.1 (− 3.0, 3.3) 0.93 | 1.4 (− 0.5,3.3) 0.15 | 0.1 (− 2.9, 3.1) 0.93 | −0.8 (− 2.9,1.1) 0.41 | 0.17 (− 3.1,3.5) 0.91 |
Fat mass (%) P value | 0.08 (− 0.70,0.86) 0.83 | 0.53 (− 0.59,1.66) 0.34 | −0.1 (− 0.9,0.6) 0.70 | −0.2 (− 1.5,0.9) 0.66 | 0.2 (− 0.5, 1.0) 0.53 | 0.5 (− 0.6,1.8) 0.3 | 0.4 (− 0.3,1.1) 0.28 | −0.8 (− 2.0,0.3) 0.14 | 0.06 (− 0.74,0.87) 0.86 | −0.2 (− 1.5, 1.1) 0.75 |
Muscle mass (%) P value | 0.2 (−41.9,42.3) 0.99 | 71.3 (10.7131.9) 0.02 | − 22.0 (− 63.9,19.8) 0.30 | − 25.7 (− 93.3,41.8) 0.45 | − 22.4 (− 62.1,17.3) 0.26 | − 26.7 (− 90.6,37.2) 0.41 | 19.7 (− 19.9,59.4) 0.32 | 1.7 (− 59.7,63.2) 0.95 | 20.3 (− 20.6,61.3) 0.32 | − 6.8 (− 73.8,60.1) 0.84 |
Trunk fat (%) P value | 0. 2 (− 0.8,1.3) 0.67 | 0.5 (− 1.0,2.1) 0.65 | − 0.06 (− 1.15, 1.02) 0.90 | −0.1 (− 1.9, 1.5) 0.84 | 0.3 (− 0.7,1.4) 0.58 | 0.7 (− 0.9,2.5) 0.38 | 0.5 (− 0.5,1.6) 0.34 | − 1.0 (− 2.7,0.6) 0.22 | 0.2 (− 0.9,1.3) 0.71 | − 0.2 (− 2.1,1.5) 0.77 |
Visceral fat P value | 0.1 (− 0.2,0.4) 0.5 | 0.2 (− 0.2,0.7) 0.37 | − 0.1 (− 0.4,0.2) | −0.1 (− 0.7,0.3) | − 0.04 (− 0.37,0.27) 0.77 | 0.3 (− 0.1,0 .8) 0.17 | 0.1 (− 0.1,0.4) 0.32 | −0.2 (− 0.7,0.2) 0.38 | −0.03 (− 0.3,0.3) 0.82 | −0.04 (− 0.6,0.5) 0.86 |
LDL, mg/dL P value | − 4.0 (− 15.0,6.8) 0.46 | − 17.9 (− 33.6, − 2.3) 0.02 | 0.6 (− 10.1,11.3) 0.90 | 7.4 (− 10.0,24.9) 0.40 | 3.9 (− 6.3,14.2) 0.44 | 2.1 (− 14.5,18.8) 0.79 | 3.2 (− 7.0,13.5) 0.53 | −2.5 (− 18.5,13.5) 0.75 | −6.5 (− 16.9,3.8) 0.21 | − 18.1 (− 35.3, − 0.9) 0.03 |
HDL, mg/dL P value | 0.9 (− 3.5,5.4) 0.68 | 2.3 (− 4.0,8.8) 0.46 | −2.2 (− 6.5,2.06) 0.30 | 0.84 (− 6.1,7.8) 0.81 | − 1.8 (− 5.9,2.3) 0.38 | 3.3 (− 3.2,10.0) 0.31 | 1.4 (−2.6.5.5) 0.48 | − 0.6 (− 7.10,5.7) 0.83 | − 0.7 (− 5.0, 3.4) 0.72 | 1.2 (− 5.7, 8.2) 0.72 |
TC, mg/dL P value | −4.1 (− 18.9,10.7) 0.58 | −4.8 (− 26.0,16.3) 0.65 | −9.7 (− 23.9,4.4) 0.17 | 3.7 (− 19.3,26.7) 0.75 | 3.8 (− 10.1,17.9) 0.58 | 11.4 (− 11.3,34.2) 0.32 | −1.2 (− 15.3,12.7) 0.85 | −3.8 (− 25.7,18.0) 0.72 | −9.8 (− 24.1, 4.4) 0.17 | −22.1 (− 45.7, 1.3) 0.06 |
TG, mg/dL P value | 6.3 (− 14.1,26.8) 0.54 | − 13.1 (− 42.4,16.2) 0.37 | 2.5 (− 17.3,22.4) 0.79 | 21.2 (− 11.0,53.6) 0.19 | 8.6 (− 10.4, 27.7) 0.37 | −4.5 (− 35.4, 26.3) 0.77 | −9.4 (− 28.4,9.5) 0.32 | 6.2 (− 23.3,35.8) 0.67 | − 3.0 (− 22.6,16.4) 0.75 | −25.9 (− 58.1, 6.2) 0.11 |