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Table 4 Haplotype block analysis of metabolic and anthropometric changes after vitamin D supplementation (4000 IU/day) for 12 weeks

From: Vitamin D receptor gene polymorphisms affecting changes in visceral fat, waist circumference and lipid profile in breast cancer survivors supplemented with vitamin D3

Variables H1 H2 H3 H4
Global-Stat P Value* FDR P Value** Global-Stat P Value* FDR P Value** Global-Stat P Value* FDR P Value** Global-Stat P Value* FDR P Value**
BMI, Kg/m2 18.87 0.27 0.65 3.89 0.79 0.92 9.94 0.19 0.65 5.61 0.46 0.72
WC, cm 10.66 0.82 0.92 5.47 0.60 0.86 8.05 0.32 0.65 6.73 0.34 0.65
HC, cm 26.97 0.04 0.25 4.68 0.69 0.92 7.33 0.39 0.66 2.88 0.82 0.92
Fat mass, cm 17.33 0.63 0.86 7.66 0.36 0.65 3.96 0.78 0.92 8.26 0.21 0.65
Muscle mass, (%) 13.50 0.85 0.92 4.28 0.74 0.92 7.60 0.36 0.65 11.36 0.07 0.34
Trunk fat, (%) 17.50 0.62 0.86 9.01 0.25 0.65 2.64 0.91 0.93 7.13 0.30 0.65
Visceral fat 45.46 < 0.001 < 0.001 3.58 0.82 0.92 79.69 < 0.001 < 0.001 7.82 0.25 0.65
LDL, mg/dL 18.90 0.27 0.65 7.53 0.37 0.65 9.37 0.22 0.65 9.20 0.16 0.64
HDL, mg/dL 27.83 0.03 0.22 16.43 0.02 0.22 5.74 0.56 0.84 9.24 0.16 0.64
TC, mg/dL 15.83 0.46 0.72 15.02 0.03 0.22 2.90 0.89 0.93 6.41 0.37 0.65
TG, mg/dL −53.73 1 1.00 3.24 0.86 0.92 13.06 0.07 0.34 13.48 0.03 0.22
  1. BMI Body mass index, WC Waist circumference, HC Hip circumference, TC Total cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, TG Triglycerides
  2. H1, Cdx2, FokI, BsmI, ApaI, TaqI; H2, Cdx2, FokI, BsmI, H3, BsmI, ApaI, TaqI; H4, FokI, BsmI, ApaI
  3. *All values were adjusted for age, baseline 25-hydroxy vitamin D (25(OH)D), energy intake, fat intake and physical activity
  4. **FDR P values were obtained using the false-discovery rate (FDR) methods