Vitamin D receptor gene polymorphisms affecting changes in visceral fat, waist circumference and lipid profile in breast cancer survivors supplemented with vitamin D3

Table 4 Haplotype block analysis of metabolic and anthropometric changes after vitamin D supplementation (4000 IU/day) for 12 weeks

Variables	H1			H2			H3			H4
Variables	Global-Stat	P _Value*	FDR P _Value**	Global-Stat	P _Value*	FDR P _Value**	Global-Stat	P _Value*	FDR P _Value**	Global-Stat	P _Value*	FDR P _Value**
BMI, Kg/m2	18.87	0.27	0.65	3.89	0.79	0.92	9.94	0.19	0.65	5.61	0.46	0.72
WC, cm	10.66	0.82	0.92	5.47	0.60	0.86	8.05	0.32	0.65	6.73	0.34	0.65
HC, cm	26.97	0.04	0.25	4.68	0.69	0.92	7.33	0.39	0.66	2.88	0.82	0.92
Fat mass, cm	17.33	0.63	0.86	7.66	0.36	0.65	3.96	0.78	0.92	8.26	0.21	0.65
Muscle mass, (%)	13.50	0.85	0.92	4.28	0.74	0.92	7.60	0.36	0.65	11.36	0.07	0.34
Trunk fat, (%)	17.50	0.62	0.86	9.01	0.25	0.65	2.64	0.91	0.93	7.13	0.30	0.65
Visceral fat	45.46	< 0.001	< 0.001	3.58	0.82	0.92	79.69	< 0.001	< 0.001	7.82	0.25	0.65
LDL, mg/dL	18.90	0.27	0.65	7.53	0.37	0.65	9.37	0.22	0.65	9.20	0.16	0.64
HDL, mg/dL	27.83	0.03	0.22	16.43	0.02	0.22	5.74	0.56	0.84	9.24	0.16	0.64
TC, mg/dL	15.83	0.46	0.72	15.02	0.03	0.22	2.90	0.89	0.93	6.41	0.37	0.65
TG, mg/dL	−53.73	1	1.00	3.24	0.86	0.92	13.06	0.07	0.34	13.48	0.03	0.22

BMI Body mass index, WC Waist circumference, HC Hip circumference, TC Total cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, TG Triglycerides
H1, Cdx2, FokI, BsmI, ApaI, TaqI; H2, Cdx2, FokI, BsmI, H3, BsmI, ApaI, TaqI; H4, FokI, BsmI, ApaI
*All values were adjusted for age, baseline 25-hydroxy vitamin D (25(OH)D), energy intake, fat intake and physical activity
**FDR P values were obtained using the false-discovery rate (FDR) methods

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