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Table 5 Total, direct, and indirect effects of VDR SNPs on LDL-C, WC and muscle mass percentage for plasma 25-hydroxy vitamin D (25(OH)D changes as the mediator

From: Vitamin D receptor gene polymorphisms affecting changes in visceral fat, waist circumference and lipid profile in breast cancer survivors supplemented with vitamin D3

Outcomes

Exposures

ACME (95% CI)a

ADE (95% CI)b

Total effect

(95% CI)

Proportion mediated 95% CI

LDL-C (mg/dL)

ApaI

aa

Aa

aa

Aa

aa

Aa

aa

Aa

−0.07 (−3.58, 3.45)

0.01 (−0.99, 1.26)

−17.92 (−34.00, −2.29)

−4.17 (−15.00, 6.35)

− 17.99 (− 34.12, −2.21)

−4.15 (− 15.10, 6.52)

0.004 (− 0.33, 0.32)

0.008 (− 0.65, 0.77)

Cdx2

GG

GA

GG

GA

GG

GA

GG

GA

−0.15 (−3.22, 2.94)

− 0.01 (−1.06, 0.87)

−17.41 (− 32.73, − 0.60)

−6.12 (− 16.10, 3.56)

−17.57 (− 32.93, − 0.73)

−6.14 (− 16.23, 3.57)

0.007 (−0.25, 0.31)

0.001 (− 0.50, 0.35)

WC (cm)

BsmI

bb

Bb

bb

Bb

bb

Bb

bb

Bb

0.01 (−0.02, 0.06)

−0.002 (− 0.02, 0.02)

0.16 (− 0.09, 0.44)

0.08 (− 0.08, 0.25)

0.17 (− 0.08, 0.46)

0.07 (− 0.09, 0.26)

0.02 (− 0.90, 0.91)

−0.003 (− 0.94, 0.85)

Muscle mass (%)

ApaI

aa

Aa

aa

Aa

aa

Aa

aa

Aa

−0.43 (−3.28, 1.66)

−0.38 (−2.21, 0.80)

−8.40 (− 23.36, 7.26)

−12.73 (− 21.86, − 3.31)

−8.83 (− 23.96, 6.75)

−13.12 (− 22.49, − 3.44)

0.01 (− 1.15, 0.93)

0.01 (−0.09, 0.19)

  1. aaverage causal mediation effects, baverage direct effects
  2. Adjusted for age, baseline Body Mass Index (BMI), energy intake, fat intake and physical activity
  3. LDL-C Low-density lipoprotein cholesterol, WC Waist circumference
  4. AA, GG and BB were considered as reference category for ApaI, Cdx2 and BsmI respectively