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Table 5 Total, direct, and indirect effects of VDR SNPs on LDL-C, WC and muscle mass percentage for plasma 25-hydroxy vitamin D (25(OH)D changes as the mediator

From: Vitamin D receptor gene polymorphisms affecting changes in visceral fat, waist circumference and lipid profile in breast cancer survivors supplemented with vitamin D3

Outcomes Exposures ACME (95% CI)a ADE (95% CI)b Total effect
(95% CI)
Proportion mediated 95% CI
LDL-C (mg/dL) ApaI aa Aa aa Aa aa Aa aa Aa
−0.07 (−3.58, 3.45) 0.01 (−0.99, 1.26) −17.92 (−34.00, −2.29) −4.17 (−15.00, 6.35) − 17.99 (− 34.12, −2.21) −4.15 (− 15.10, 6.52) 0.004 (− 0.33, 0.32) 0.008 (− 0.65, 0.77)
Cdx2 GG GA GG GA GG GA GG GA
−0.15 (−3.22, 2.94) − 0.01 (−1.06, 0.87) −17.41 (− 32.73, − 0.60) −6.12 (− 16.10, 3.56) −17.57 (− 32.93, − 0.73) −6.14 (− 16.23, 3.57) 0.007 (−0.25, 0.31) 0.001 (− 0.50, 0.35)
WC (cm) BsmI bb Bb bb Bb bb Bb bb Bb
0.01 (−0.02, 0.06) −0.002 (− 0.02, 0.02) 0.16 (− 0.09, 0.44) 0.08 (− 0.08, 0.25) 0.17 (− 0.08, 0.46) 0.07 (− 0.09, 0.26) 0.02 (− 0.90, 0.91) −0.003 (− 0.94, 0.85)
Muscle mass (%) ApaI aa Aa aa Aa aa Aa aa Aa
−0.43 (−3.28, 1.66) −0.38 (−2.21, 0.80) −8.40 (− 23.36, 7.26) −12.73 (− 21.86, − 3.31) −8.83 (− 23.96, 6.75) −13.12 (− 22.49, − 3.44) 0.01 (− 1.15, 0.93) 0.01 (−0.09, 0.19)
  1. aaverage causal mediation effects, baverage direct effects
  2. Adjusted for age, baseline Body Mass Index (BMI), energy intake, fat intake and physical activity
  3. LDL-C Low-density lipoprotein cholesterol, WC Waist circumference
  4. AA, GG and BB were considered as reference category for ApaI, Cdx2 and BsmI respectively