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Fig. 10 | Lipids in Health and Disease

Fig. 10

From: 4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters

Fig. 10

Effect of 4-cholesten-3-one treatment on MDA-MB-231 cell migration. Wound healing assay: cells were scratched and then incubated with 75 μM 4-cholesten-3-one for 48 h. Images were captured after the indicated times. (a) Representative images of cell migration. (b) The gap distance was quantitatively determined using MESURIM software after 48 h. The scratch width was measured as a percentage of the initial gap (the scratch width at 0 h was assumed to be 0% for both conditions). Transwell migration assay: cells were treated or not with 12.5 μM 4-cholesten-3-one and their migration capacity was determined by the Transwell assay after 24 h of incubation. (c) Representative images of the Transwell assay at × 40 and × 100 microscope magnification

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Lipids in Health and Disease

ISSN: 1476-511X