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Fig. 8 | Lipids in Health and Disease

Fig. 8

From: 4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters

Fig. 8

Effect of 4-cholesten-3-one on cell viability after LXRα and LXRβ knockdown. Cells were transfected or not with a siRNA specific for LXRα and LXRβ (20 nM) or a siRNA control. After 48 h of incubation, the cells were treated or not with 4-cholesten-3-one at the concentrations indicated. (a) LXRα and LXRβ relative mRNA expression determined by RT-qPCR after 48 h of transfection time. (b) Cell viability of MCF-7 and MDA-MB-231 cells after transfection and treatment with 4-cholesten-3-one. All data were presented as mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001. ns means not significant

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Lipids in Health and Disease

ISSN: 1476-511X