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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Sialic acid metabolism as a potential therapeutic target of atherosclerosis

Fig. 1

The summary of mammalian Sia metabolism and the Neu5Ac-activated signaling pathway in cardiomyocyte. Legend: In eukaryotic cells, Neu5Ac is synthesized in cytoplasm and transferred to nucleus for cytosine 5′-monophosphate (CMP)-Neu5Ac synthesis by CMP-Neu5Ac activating acid. Then, it is transmitted to Golgi apparatus to form glycoconjugates by ST, which is subsequently secreted or delivered to cell surface. N-Acetyl-Neuraminic Acid (Neu5Ac) as a signaling molecule to trigger myocardial injury via activation of Rho/ROCK-JNK/ERK signaling pathway in acute myocardial infarction

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