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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Terminalia Arjuna bark extract impedes foam cell formation and promotes apoptosis in ox-LDL-stimulated macrophages by enhancing UPR-CHOP pathway

Fig. 5

Proposed model depicting the underlying molecular mechanism by which aqueous bark extract of T. arjuna exerts pro-apoptotic effect on macrophage and foam cells. TA promotes macrophage and foam cell apoptosis by directly modulating JNK, p38MAPK-CHOP pathway in a DUSP1-dependent manner (indicated by red coloured lines), and may also augment ox-LDL induced UPR-mediated activation of JNK and p38MAPK-CHOP cascade (black coloured lines), suggesting a possible interplay between the ER stress- and TA-mediated MAPK signaling (denoted by bidirectional arrow)

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