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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c

Fig. 2

FoxO3 loss-of-function inhibits triglyceride accumulation in HepG2 cells. a Protein analysis of FoxO3 in HepG2 cells transduced with three small interfering RNAs (FoxO3 si1, si2, and si3) or a negative control for 24 h. b Representative morphology of Oil red O staining of HepG2 cells treated with FoxO3 siRNA1 or negative control for 24 h and then challenged with or without high glucose and high palmitic acid (HFHG) for another 24 h. c Analysis of cellular TG concentrations of HepG2 cells transduced with FoxO3 si1, si2, si3 or negative control for 24 h and treated with or without HFHG for another 24 h. The data are presented as the means ± SEM. *P < 0.05 versus control, #P < 0.05 versus HFHG

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