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Table 2 Main characteristics of patients enrolled among trials included in the meta-analysis

From: Association of statin use and clinical outcomes in heart failure patients: a systematic review and meta-analysis

Study, year Arms No EF % Age Year BMI Male % DM % HTN % Smoking % TC mmol/L Triglyceride mmol/L
Horwich et al. 2004 S
C
200
250
≤40%
≤40%
57 ± 11
48 ± 13
28.2 ± 6.2
26.9 ± 6.2
82
70
33
16
64
43
80
66
4.32 ± 1.25
4.2 ± 1.5
1.87 ± 1.3
1.98 ± 2.17
Sola et al. 2005 S
C
225
191
≤35%
≤35%
55.4 ± 6.4
53.8.4 ± 5.7
24.3 ± 3.8
23.5 ± 4.3
62
63
24
27
41
36
34
30
NR
NR
2.8 ± 0.5
2.9 ± 0.4
Fukuta et al. 2005 S
C
69
68
≥50%
≥50%
65 ± 2
65 ± 16
NR
NR
51
45
34
12
87
72
NR
NR
6.07 ± 2.22
4.67 ± 1
2.31 ± 2.21
1.64 ± 0.90
Hong et al. 2005 S
C
106
96
≤40%
≤40%
61.8 ± 10.3
60.9 ± 10.4
NR
NR
72
75
32
28
41
44
57
52
NR
NR
NR
NR
Go et al. 2006 S
C
12,648
11,950
≤40%
≤40%
69.6 ± 10.3
72.9 ± 11.4
NR
NR
62
60
55.7
41.3
89
83
NR
NR
5.37 ± 1.14
5.68 ± 1.22
NR
NR
Kjekshus et al. 2007 S
C
2514
2497
≤40%
≤40%
73 ± 7.1
73 ± 7.0
27 ± 4.5
27 ± 4.6
76
76
30
29
63
63
9
8
5.36 ± 1.11
5.35 ± 1.06
2.01 ± 1.33
1.99 ± 1.23
Huan et al. 2007 S
C
377
102
≤40%
≤40%
74 ± 4
74 ± 3
26.5
28.1
66
77
NR
NR
NR
NR
75
72
5.1 ± 0.25
5.5 ± 0.3
NR
NR
Coleman et al. 2008 S
C
642
562
≤30%
≤30%
67.5 ± 13
64.5 ± 10.8
NR
NR
80.7
76.2
31.5
30.2
43.8
34.9
NR
NR
NR
NR
NR
NR
Roik et al. 2008 S
C
103
43
≥45%
≥45%
69 ± 11
66 ± 16
28.6 ± 4.8
27.2 ± 4.9
50.5
58
25
12
76
58
43
34
4.57 ± 1.37
4.57 ± 1.03
1.64 ± 1.08
1.62 ± 1.05
Tavazzi et al. 2008 the GISSI-HF trial S
C
2285
2289
33.4
33.4
68 ± 1
68 ± 1
27·1 ± 4.6
27.71 ± 4.4
78.6
76.8
25
27.4
53.5
55.1
14.1
14
NR
NR
NR
NR
Gomez-Soto et al. 2010 S
C
1343
1230
≥47%
≥47%
71.5 ± 6.9
69.8 ± 7.8
NR
NR
51.6
43.9
36.8
47.7
45.6
48.5
33
31
NR
NR
NR
NR
Kaneko et al. 2013 S
C
459
665
≥50%
≥50%
65.6 ± 11.7* 24.3 ± 3.6* 76.2* 32.4* 64.5* 24.2* NR
NR
NR
NR
Yap et al. 2015 S
C
457
293
≥50%
≥50%
73.1 ± 10.6* 26.5* 35.3* 47.1* 80.3* NR
NR
NR
NR
NR
NR
Nochioka et al. 2015 S
C
1163
1961
≥50%
≥50%
69.0 ± 11.0
69.7 ± 12.9
67.5
64
45
40.8
33.8
20.9
85
76.7
45
40.8
NR
NR
1.51 ± 0.82
1.4 ± 0.81
Alehagen U et al.
2015
S
C
3427
5713
≥50%
≥50%
78 ± 12
75 ± 9
29 ± 6
27 ± 6
54
42
31
28
62
64
NR
NR
NR
NR
NR
NR
Alehagen et al. 2015 S
C
10,345
11,519
< 40%
< 40%
72 10
72 ± 14
27 ± 5
26 ± 5
75
68
33
18
48
39
41
49
NR
NR
NR
NR
Tsujimoto et al. 2018 S
C
1765
1613
≥50%
≥50%
69 ± 9.6
68.1 ± 9.6
NR
NR
55
42
42.9
20.8
93.1
89.8
10.5
10.6
NR
NR
NR
NR
  1. Abbreviations: S: statins; C: control; HTN: hypertension; DM: diabetes mellitus; TC: total cholesterol; EF: ejection fraction; NR: not-reported; *: only whole group represented