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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling

Fig. 6

Paradoxical roles of AMPK and SREBP-1c in NS5A-induced hepatic steatosis. a qRT-PCR analysis of the mRNA levels of FASN and ACC1 in Hepa1–6 cells co-transfected with NS5A and SREBP-1c. b and c The expression levels of SREBP-1c, ACC1 and FASN were analyzed by Western blotting in Hepa1–6 and HepG2 cells after co-transfection with NS5A and SREBP-1c. d and e The accumulation of lipid droplets in HepG2 cells was visualized by Oil Red O staining. Oil Red O extracted with isopropanol was measured at OD520. The Data are representative of three independent experiments. NS (no significance), *P < 0.05, **P < 0.01, ***P < 0.001

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