System | Drug | Polymer | Dosage form | Plasma level | reference |
---|---|---|---|---|---|
Buccal drug delivery | Lovastatin | Carbapol 934P, PVP K30, HPMC K4M, HPMC K100 M | Buccoadhesive pill | NM | [13] |
Buccal drug delivery | Pravastatin sodium | Carrageenan gum | Bilayered buccal pills | NM | [37] |
Mucoadhesive drug delivery | Simvastatin | Hydroxy propyl beta cyclodextrin (HPBCD) | Microcapsules | NM | [16] |
Mucoadhesive drug delivery | Simvastatin | Sod.Alginate: Methyl cellulose (F10) | Microspheres | NM | [17] |
Gastric floating | Pravastatin | Hpmc k4 m, hpmc k15 m, and hpmc k100 m. | Floating pills | NM | [19] |
Pulsatile drug Delivery | Lovastatin | Karaya gum/kondagogu Gum/xanthum gum/guar gum | Microspheres | NM | [21] |
Local drug delivery | Simvastatin | – | Local delivery | NM | [23] |
Intravenous drug delivery | Rosuvastatin | – | Rosuvastatin was dissolved in normal saline and administered intravenously | 0.5 ng/ml (with the 0.2 mg/kg dose) | [24] |
Transdermal drug delivery | Simvastatin | Sorbitan monolaurate and sorbitan monostearate (span 20 and 60 | Niosomal gel | NM | [28] |
Transdermal drug delivery | Pitavastatin | Phospholipids and soybean oil | Gel | 301 ng/mL 8 h 10 ng/mL for at least 15 days | [29] |
Nasal drug delivery | Simvastatin | – | Jet nebulizer | 0.260 μg/ml during 6 h(with the 5 mg/ml dose, 10 min) | [32] |
Nasal drug delivery | Simvastatin | – | Intranasal | NM | [33] |
Implantable drug delivery systems | Simvastatin | Polylactic acid | Gel | NM | [35] |
Implantable drug delivery systems | Simvastatin | Polylactic acid/polyglycolic acid | Implant | NM | [36] |