Parenteral systems for statin delivery: a review

Table 1 Examples of parenteral statin delivery systems

System	Drug	Polymer	Dosage form	Plasma level	reference
Buccal drug delivery	Lovastatin	Carbapol 934P, PVP K30, HPMC K4M, HPMC K100 M	Buccoadhesive pill	NM	[13]
Buccal drug delivery	Pravastatin sodium	Carrageenan gum	Bilayered buccal pills	NM	[37]
Mucoadhesive drug delivery	Simvastatin	Hydroxy propyl beta cyclodextrin (HPBCD)	Microcapsules	NM	[16]
Mucoadhesive drug delivery	Simvastatin	Sod.Alginate: Methyl cellulose (F10)	Microspheres	NM	[17]
Gastric floating	Pravastatin	Hpmc k4 m, hpmc k15 m, and hpmc k100 m.	Floating pills	NM	[19]
Pulsatile drug Delivery	Lovastatin	Karaya gum/kondagogu Gum/xanthum gum/guar gum	Microspheres	NM	[21]
Local drug delivery	Simvastatin	–	Local delivery	NM	[23]
Intravenous drug delivery	Rosuvastatin	–	Rosuvastatin was dissolved in normal saline and administered intravenously	0.5 ng/ml (with the 0.2 mg/kg dose)	[24]
Transdermal drug delivery	Simvastatin	Sorbitan monolaurate and sorbitan monostearate (span 20 and 60	Niosomal gel	NM	[28]
Transdermal drug delivery	Pitavastatin	Phospholipids and soybean oil	Gel	301 ng/mL 8 h 10 ng/mL for at least 15 days	[29]
Nasal drug delivery	Simvastatin	–	Jet nebulizer	0.260 μg/ml during 6 h(with the 5 mg/ml dose, 10 min)	[32]
Nasal drug delivery	Simvastatin	–	Intranasal	NM	[33]
Implantable drug delivery systems	Simvastatin	Polylactic acid	Gel	NM	[35]
Implantable drug delivery systems	Simvastatin	Polylactic acid/polyglycolic acid	Implant	NM	[36]

ISSN: 1476-511X