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Table 3 Effect of LDL-C on EBB-induced refractory hemorrhage in subgroups

From: Low-density lipoprotein cholesterol levels are positively associated with the risk of endobronchial biopsy-induced refractory hemorrhage in patients with lung cancer

Characteristic Number of patients β(95%CI) P for interaction
 Gender    0.0256
  Female 143 0.60 (0.12, 2.91)  
  Male 516 3.81 (1.88, 7.72)  
 Smoking    0.6460
  Yes 242 2.86 (1.38, 5.96)  
  No 417 2.12 (0.68, 6.60)  
 Hypertension    0.8006
  Yes 162 2.46 (1.08, 5.60)  
  No 497 2.68 (1.39, 5.19)  
 Diabetes mellitus    0.9991
  Yes 32 0.00 (0.00, inf)  
  No 627 2.75 (1.44, 5.27)  
 CHD    0.9994
  Yes 23 inf. (0.00, inf)  
  No 636 2.59 (1.33, 5.05)  
 COPD    0.5498
  Yes 612 5.73 (0.41, 79.26)  
  No 47 2.65 (1.36, 5.14)  
 Location of the lesion    0.6326
  Peripheral bronchi 560 2.65 (1.31, 5.35)  
  Central airway 99 3.84 (0.94, 15.58)  
 Stage    0.7970
  Early 353 2.76 (1.27, 5.99)  
  Advanced 306 2.38 (0.93, 6.10)  
 Histological type    0.1136
  Adenocarcinoma 176 0.37 (0.05, 2.48)  
  Squamous cell carcinoma 331 4.61 (1.98, 10.71)  
  SCLC 116 2.85 (0.48, 16.94)  
  Othera 36 inf. (0.00, inf)  
  1. Adjusted for gender, location of the lesion, histological type, smoking, SBP, hemoglobin, neutrophil percentage, PT, APTT, CRP, ALT, triglyceride, HDL-C, apolipoprotein B, and apolipoprotein E; in each case, the model was not adjusted for the stratification variable. a“Other” includes histological types of NSCLC (not specified, n = 12), neuroendocrine carcinoma (n = 7), adenosquamous carcinoma (n = 5), muco-epidermoid carcinoma (n = 2), adenoid cystic carcinoma (n = 1), carcinosarcoma (n = 1) and lung cancer without histological type specified (n = 8). LDL-C, low-density lipoprotein cholesterol; EBB endobronchial biopsy; CHD, coronary heart disease; COPD, chronic obstructive pulmonary disease; NSCLC, non-small cell lung carcinoma; SBP, systolic blood pressure; PT, prothrombin time; APTT, activated partial thromboplastin time; CRP, C-reactive protein; ALT, alanine aminotransferase; HDL-C, high-density lipoprotein cholesterol