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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism

Fig. 2

Analysis of lipid metabolism in ACE2-overexpressing C2C12 cells and Ad-ACE2-treated db/db mice. a: Relative ACE2 expression level in ACE2-overexpressing C2C12 cells. b: Relative gene expression levels of fatty acid oxidation-related genes (PGC-1α, PPARα, PPARγ, CPT-1α, and MCAD). c: Relative ACE2 expression level in skeletal muscle of Ad-ACE2-treated db/db mice. d: Analysis of intramuscular triglyceride concentration in skeletal muscle of Ad-ACE2-treated db/db mice. e: Relative gene expression levels of fatty acid oxidation-related genes (PGC-1α, PPARα, PPARγ, CPT-1α, and MCAD). f: Relative protein levels of lipid-metabolizing (SREBP-1c and ACCα). The data are presented as the mean ± SD of n = 3 independent experiments in C2C12 cells, n = 3 in Ad-ACE2-treated db/db mice. *P < 0.05 and **P < 0.01 versus Ad-GFP cell or Ad-GFP-treated mice by Student’s t test

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