The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice

Table 1 Effects of ATGL deficiency in mice on lipid metabolism across various tissues compared to control littermates

Tissue of Interest
Tissue-knockout	Liver	WAT	BAT	Heart	Skeletal Muscle
Global^a	TG accumulation Decreased TG synthesis Decreased FFA oxidation	TG accumulation Decreased TG synthesis	TG accumulation Decreased TG synthesis No change in FFA oxidation	TG accumulation Decreased TG synthesis Decreased FFA oxidation	TG accumulation Decreased FFA oxidation
Liver^b	TG accumulation Decreased TG synthesis Decreased FFA oxidation	No change	No change	No change	No change
Adipose^c	Decreased fasting TG	TG accumulation Decreased TG synthesis	TG accumulation Decreased TG synthesis	No change	No change
BAT^d	Unknown	No change	TG accumulation Decreased TG synthesis No change in oxidation	Unknown	No change
Heart^e	Unknown	Unknown	Unknown	TG accumulation Decreased TG synthesis Decreased FFA oxidation	No Change
Skeletal muscle^f	Unknown	Unknown	Unknown	Unknown	TG accumulation
Pancreas^g	Unknown	Increased TG lipolysis	Increased FFA oxidation	Unknown	Unknown

^a key reference: [15], ^b key references: [55, 56], ^c key references: [28, 33, 34], ^d key references: [31, 32], ^e key references: [17,18,19,20], ^f key references: [36, 39, 47], ^g key references: [25, 61, 62]

ISSN: 1476-511X