Skip to main content

Table 1 Effects of ATGL deficiency in mice on lipid metabolism across various tissues compared to control littermates

From: The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice

Tissue of Interest
Tissue-knockout Liver WAT BAT Heart Skeletal Muscle
Globala TG accumulation
Decreased TG synthesis
Decreased FFA oxidation
TG accumulation Decreased TG synthesis TG accumulation
Decreased TG synthesis
No change in FFA oxidation
TG accumulation
Decreased TG synthesis
Decreased FFA oxidation
TG accumulation
Decreased FFA oxidation
Liverb TG accumulation
Decreased TG synthesis
Decreased FFA oxidation
No change No change No change No change
Adiposec Decreased fasting TG TG accumulation
Decreased TG synthesis
TG accumulation
Decreased TG synthesis
No change No change
BATd Unknown No change TG accumulation
Decreased TG synthesis
No change in oxidation
Unknown No change
Hearte Unknown Unknown Unknown TG accumulation
Decreased TG synthesis
Decreased FFA oxidation
No Change
Skeletal musclef Unknown Unknown Unknown Unknown TG accumulation
Pancreasg Unknown Increased TG lipolysis Increased FFA oxidation Unknown Unknown
  1. a key reference: [15], b key references: [55, 56], c key references: [28, 33, 34], d key references: [31, 32], e key references: [17,18,19,20], f key references: [36, 39, 47], g key references: [25, 61, 62]