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Table 1 Effects of ATGL deficiency in mice on lipid metabolism across various tissues compared to control littermates

From: The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice

Tissue of Interest
Tissue-knockoutLiverWATBATHeartSkeletal Muscle
GlobalaTG accumulation
Decreased TG synthesis
Decreased FFA oxidation
TG accumulation Decreased TG synthesisTG accumulation
Decreased TG synthesis
No change in FFA oxidation
TG accumulation
Decreased TG synthesis
Decreased FFA oxidation
TG accumulation
Decreased FFA oxidation
LiverbTG accumulation
Decreased TG synthesis
Decreased FFA oxidation
No changeNo changeNo changeNo change
AdiposecDecreased fasting TGTG accumulation
Decreased TG synthesis
TG accumulation
Decreased TG synthesis
No changeNo change
BATdUnknownNo changeTG accumulation
Decreased TG synthesis
No change in oxidation
UnknownNo change
HearteUnknownUnknownUnknownTG accumulation
Decreased TG synthesis
Decreased FFA oxidation
No Change
Skeletal musclefUnknownUnknownUnknownUnknownTG accumulation
PancreasgUnknownIncreased TG lipolysisIncreased FFA oxidationUnknownUnknown
  1. a key reference: [15], b key references: [55, 56], c key references: [28, 33, 34], d key references: [31, 32], e key references: [17,18,19,20], f key references: [36, 39, 47], g key references: [25, 61, 62]