The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice

Table 2 Effects of ATGL deficiency in mice on glucose metabolism across various tissues compared to control littermates

Tissue of Interest
Tissue-knockout	Liver	WAT	BAT	Heart	Skeletal muscle
Global^a	Increased gluconeogenesis Decreased fasting glycogen	Increased uptake Increased glucose oxidation	Increased glucose oxidation	Decreased glycolysis	Increased glucose oxidation
Liver^b	No change	No change	No change	No change	No change
Adipose^c	Increased gluconeogenesis Decreased glycogen levels	Increased glucose uptake	Increased glucose oxidation	Increased glucose oxidation	Increased glucose oxidation
BAT^d	Unknown	Unknown	No change	Unknown	No change
Heart^e	Unknown	Unknown	Unknown	Decreased glycolysis	No change
Skeletal muscle^f	No change	No change	No change	No change	No change
Pancreas^g	Unknown	Unknown	Unknown	Unknown	Unknown

^a key reference: [15], ^b key references: [55, 56], ^c key references: [28, 33, 34], ^d key references: [31, 32], ^e key references: [17,18,19,20], ^f key references: [36, 39, 47], ^g key references: [25, 61, 62]

ISSN: 1476-511X