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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Deletion of the Mir-106b~ 25 MicroRNA cluster attenuates atherosclerosis in Apolipoprotein E knockout mice

Fig. 1

Expression and effect of miR-106b~ 25 cluster members in atherosclerosis progression (a) Relative expression of the miR-106b~ 25 cluster members determined by quantitative real-time PCR in aortas of 6 week or 36 week old ApoE KO mice (n = 8). b Relative expression of the miR-106b~ 25 cluster members determined by quantitative real-time PCR in murine endothelial cells subjected to oxidized (Ox) LDL treatment (20 μg/ml) for 1 h, 6 h or 24 h (*, P < 0.05). Relative expression was determined by qRT–PCR with specific primers for miR-25, miR-106b and miR-93. The results were derived by the DDCt method and were normalized to the expression of U6. c Plaque area as determined in the aortic sinus of ApoE KO (n = 8) or double KO mice (n = 8) aged 36 weeks. (**, P < 0.005). Representative Oil-red-O staining images of atherosclerotic plaques in the aortic sinus of (d) ApoE KO mice and (e) Double KO mice. f Fibrotic cap coverage of atherosclerotic plaques determined by Masson-trichrome staining. Representative images of (g) ApoE KO and (h) Double KO mice

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