Fig. 3

Relative expression as determined by real-time PCR of genes pertaining to cholesterol biosynthesis or uptake. Expression levels were determined in (a) Spleen of wild-type or 106b~ 25 KO mice fed with standard chow (n = 8 for each) (b) Spleen of wild-type or miR-106b~ 25 KO mice fed with high fat atherogenic diet for 4 weeks (n = 4 for each). c Liver of wild-type or 106b~ 25 KO mice fed with standard chow (n = 4 for each) (d) Liver of wild-type or miR-106b~ 25 KO mice fed with a high fat atherogenic diet for 4 weeks (n = 4 for each). (E) Clearance of FITC-VLDL from the plasma of ApoE KO mice or double KO mice 15 min following intravenous injection (100 μg/ mouse, n = 6 for each, *P < 0.05)