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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Sequence analysis and variant identification at the APOC3 gene locus indicates association of rs5218 with BMI in a sample of Kuwaiti’s

Fig. 5

Linkage disequilibrium structure and haplotypic architecture in APOC3. a Haploview plot defining haplotype block structure of the APOC3 gene locus. Haplotype blocks are outlined in bold. Shading indicates strength of linkage disequilibrium between the SNPs as measured by r2, which is provided in the intersecting squares. r2 is not displayed for squares with r2 = 1. A diagram of the APOC3 gene structure is provided over the plot where the first and last SNPs are on the left and right sides of the diagram, respectively. Under the SNP ID numbers are the index numbers, shown in bold, for the SNPs based on the map file. b Haplotypes in the haplotype blocks across the APOC3. There are three haplotype blocks across the gene. The haplotype frequencies are shown to the right of each haplotype. Only haplotypes having a frequency > 1% are shown. The SNP numbers across the top of the haplotypes correspond to those in the Haploview plot. A multiallelic D′ statistic, which indicates the level of recombination between two blocks, is shown in the crossing area. Connections from one block to the next were shown for haplotypes of > 10% frequency with thick lines and > 1% frequency with thin lines

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