Sequence analysis and variant identification at the APOC3 gene locus indicates association of rs5218 with BMI in a sample of Kuwaiti’s

Table 3 Genotypic and allelic frequencies for the 5 selected APOC3 SNPs (n = 733) that were genotyped by Realtime PCR

SNPs		Genotypic frequencies (n = 733)			Allelic frequencies		*P-value for HWE
SNPs		AA	AM	MM	Allelic frequencies		*P-value for HWE
1	rs5128 (g.8017G > C)	0.06 n = 44	0.26 n = 190	0.68 n = 499	G = 0.19	C = .81	< 0.005
2	rs2854117 (g.4546C > T)	0.40 n = 292	0.45 n = 334	0.15 n = 107	C = 0.63	T = 0.37	< 0.005
3	rs2070668 (g.5530 T > G)	0.18 n = 131	0.47 n = 344	0.35 n = 258	T = 0.41	G = 0.59	> 0.05
4	KUAPOC3N2 (g.5196A > G)	0.9998 n = 732	0.0002 n = 1	0 n = 0	A = 0.9997	G = 0.0003	< 0.005
5	KUAPOC3N3 (g. 5536G > A)	0.984 n = 721	0.016 n = 12	0 n = 0	G = 0.999	A = 0.001	> 0.05

SNP Single nucleotide polymorphism, A ancestral allele and M mutant allele, HWE Hardy-Weinberg Equilibrium
*significance value set at p<0.05

ISSN: 1476-511X