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Table 3 Laboratory characteristics of patients with sickle cell disease and controls (median, min-max)

From: Altered HDL particle in sickle cell disease: decreased cholesterol content is associated with hemolysis, whereas decreased Apolipoprotein A1 is linked to inflammation

 SCD Patients (N = 35)Controls (N = 19)P value
Age (years)13.5 ± 4.113.5 ± 3.50.557
Gender (Boys/Girls)20/1510/90.597
TG (mg/dL)127 (58–246)89 (54–223)0.042
TC (mg/dL)116 (76–170)167 (117–240)0.000
HDL-C (mg/dL)28 (20–43)50 (32–82)0.000
LDL-C (mg/dL)70 (44–106)106 (62–143)0.000
VLDL-C (mg/dL)25 (12–49)18 (11–45)0.035
Apo A1 (mg/dL)134 (94–378)198 (136–268)0.000
Apo B (mg/dL)73 (54–202)82 (55–107)0.016
LCAT (U/L)133 (8–457)285 (113–1190)0.441
LDH (U/L)487 (251–1122)205 (122–293)0.000
T. Bilirubin (mg/dL)1.7 (0.3–4.4)0.2 (0.1–0.6)0.000
D. Bilirubin (mg/dL)0.4 (0.1–0.9)0.1 (0.0–0.1)0.000
Hemin (mg/dL)2.80 (0.01–22.16)0.01 (0–0.27)0.000
Serum Iron (μg/dL)81 (39–237)65 (14–143)0.385
Ferritin (ng/mL)112 (35–1293)13 (6–46)0.000
Uric acid (mg/dL)4.7 (3.4–8.3)4.0 (2.3–6.3)0.025
SAA (mg/dL)1.14 (0.27–2.63)0.80 (0.27–1.69)0.041
MPO (μg/L)76 (34–189)43 (29–56)0.000
ALT (U/L)21 (10–86)12 (3–36)0.000
GGT (U/L)14 (8–180)12 (3–24)0.023
  1. SCD: sickle cell disease, TG: triglycerides, TC: total cholesterol, HDL-C: high-density lipoprotein cholesterol, LDL-C: low density lipoprotein cholesterol, VLDL-C: very low density lipoprotein cholesterol, Apo A1: apolipoprotein A1, Apo B: apolipoprotein B, FFA: free fatty acids, LCAT: lecithin acyl cholesterol transferase, LDH: lactate dehydrogenase, SAA: serum amyloid A, MPO: myeloperoxidase, ALT: alanine transaminase, GGT: gamma-glutamyl transferase