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Table 2 Mean (±SD) values of calculated LDL-C by eight formulae for various TG ranges and their correlation with directly measured LDL-C

From: Evaluation of eight formulas for LDL-C estimation in Iranian subjects with different metabolic health statuses

Method

Mean ± SD (mmol/L)

Mean Difference (mmol/L)

Correlation (r)

p-value obtained by paired t-test

TG < 0.56 mmol/L (n = 66)

 Direct LDL-C

1.84 ± 0.43

   

 Friedewald LDL-C

2.05 ± 0.50

0.21

0.913

0.0001

 Chen LDL-C

1.93 ± 0.46

0.09

0.908

0.0001

 de Cordova LDL-C

1.71 ± 0.39

−0.13

0.902

0.0001

 Hattori LDL-C

1.92 ± 0.47

0.08

0.913

0.001

 Anandaraja LDL-C

2.45 ± 0.56

0.61

0.865

0.0001

 Vujovic LDL-C

2.11 ± 0.50

0.27

0.910

0.0001

 Ahmadi LDL-C

2.39 ± 0.47

0.55

0.857

0.0001

 Puavillai LDL-C

2.09 ± 50

0.24

0.911

0.0001

TG 0.56–1.69 mmol/L (n = 1727)

 Direct LDL-C

2.43 ± 0.59

   

 Friedewald LDL-C

2.63 ± 0.72

0.20

0.967

0.0001

 Chen LDL-C

2.57 ± 0.66

0.14

0.973

0.0001

 de Cordova LDL-C

2.36 ± 0.57

−0.07

0.971

0.0001

 Hattori LDL-C

2.47 ± 0.68

0.03

0.967

0.0001

 Anandaraja LDL-C

2.88 ± 0.75

0.44

0.915

0.0001

 Vujovic LDL-C

2.77 ± 0.73

0.33

0.971

0.0001

 Ahmadi LDL-C

3.88 ± 0.84

1.45

0.852

0.0001

 Puavillai LDL-C

2.7 ± 0.72

0.28

0.971

0.0001

TG 1.7–3.38 mmol/L (n = 817)

 Direct LDL-C

2.75 ± 0.66

   

 Friedewald LDL-C

2.81 ± 0.85

0.06

0.898

0.0001

 Chen LDL-C

2.95 ± 0.77

0.19

0.903

0.0001

 de Cordova LDL-C

2.89 ± 0.66

0.14

0.897

0.0001

 Hattori LDL-C

2.63 ± 0.80

−0.11

0.897

0.0001

 Anandaraja LDL-C

2.90 ± 0.90

0.15

0.894

0.0001

 Vujovic LDL-C

3.09 ± 0.85

0.34

0.902

0.0001

 Ahmadi LDL-C

5.89 ± 1.00

3.14

0.712

0.0001

 Puavillai LDL-C

2.99 ± 0.85

0.23

0.922

0.0001

TG 3.39–4.51 mmol/L (n = 77)

 Direct LDL-C

2.79 ± 0.68

   

 Friedewald LDL-C

2.57 ± 0.92

−0.21

0.976

0.0001

 Chen LDL-C

3.02 ± 0.81

0.23

0.978

0.0001

 de Cordova LDL-C

3.27 ± 0.67

0.48

0.973

0.0001

 Hattori LDL-C

2.40 ± 0.86

−0.39

0.976

0.0001

 Anandaraja LDL-C

2.60 ± 0.98

−0.18

0.978

0.0001

 Vujovic LDL-C

3.05 ± 0.91

0.26

0.978

0.0001

 Ahmadi LDL-C

8.27 ± 0.80

5.48

0.793

0.0001

 Puavillai LDL-C

2.87 ± 0.92

0.07

0.977

0.020

TG > 4.51 mmol/L (n = 65)

 Direct LDL-C

2.59 ± 0.63

  

0.0001

 Friedewald LDL-C

2.07 ± 1.06

−0.52

0.884

0.0001

 Chen LDL-C

3.04 ± 0.83

0.44

0.886

0.0001

 de Cordova LDL-C

3.77 ± 0.80

1.17

0.622

0.0001

 Hattori LDL-C

1.92 ± 1.01

−0.67

0.882

0.0001

 Anandaraja LDL-C

2.11 ± 1.13

−0.48

0.913

0.0001

 Vujovic LDL-C

2.87 ± 0.95

0.27

0.909

0.0001

 Ahmadi LDL-C

11.88 ± 3.3

9.28

−0.053

0.0001

 Puavillai LDL-C

2.56 ± 0.99

−0.03

0.906

0.592