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Table 2 Mean (±SD) values of calculated LDL-C by eight formulae for various TG ranges and their correlation with directly measured LDL-C

From: Evaluation of eight formulas for LDL-C estimation in Iranian subjects with different metabolic health statuses

MethodMean ± SD (mmol/L)Mean Difference (mmol/L)Correlation (r)p-value obtained by paired t-test
TG < 0.56 mmol/L (n = 66)
 Direct LDL-C1.84 ± 0.43   
 Friedewald LDL-C2.05 ± 0.500.210.9130.0001
 Chen LDL-C1.93 ± 0.460.090.9080.0001
 de Cordova LDL-C1.71 ± 0.39−0.130.9020.0001
 Hattori LDL-C1.92 ± 0.470.080.9130.001
 Anandaraja LDL-C2.45 ± 0.560.610.8650.0001
 Vujovic LDL-C2.11 ± 0.500.270.9100.0001
 Ahmadi LDL-C2.39 ± 0.470.550.8570.0001
 Puavillai LDL-C2.09 ± 500.240.9110.0001
TG 0.56–1.69 mmol/L (n = 1727)
 Direct LDL-C2.43 ± 0.59   
 Friedewald LDL-C2.63 ± 0.720.200.9670.0001
 Chen LDL-C2.57 ± 0.660.140.9730.0001
 de Cordova LDL-C2.36 ± 0.57−0.070.9710.0001
 Hattori LDL-C2.47 ± 0.680.030.9670.0001
 Anandaraja LDL-C2.88 ± 0.750.440.9150.0001
 Vujovic LDL-C2.77 ± 0.730.330.9710.0001
 Ahmadi LDL-C3.88 ± 0.841.450.8520.0001
 Puavillai LDL-C2.7 ± 0.720.280.9710.0001
TG 1.7–3.38 mmol/L (n = 817)
 Direct LDL-C2.75 ± 0.66   
 Friedewald LDL-C2.81 ± 0.850.060.8980.0001
 Chen LDL-C2.95 ± 0.770.190.9030.0001
 de Cordova LDL-C2.89 ± 0.660.140.8970.0001
 Hattori LDL-C2.63 ± 0.80−0.110.8970.0001
 Anandaraja LDL-C2.90 ± 0.900.150.8940.0001
 Vujovic LDL-C3.09 ± 0.850.340.9020.0001
 Ahmadi LDL-C5.89 ± 1.003.140.7120.0001
 Puavillai LDL-C2.99 ± 0.850.230.9220.0001
TG 3.39–4.51 mmol/L (n = 77)
 Direct LDL-C2.79 ± 0.68   
 Friedewald LDL-C2.57 ± 0.92−0.210.9760.0001
 Chen LDL-C3.02 ± 0.810.230.9780.0001
 de Cordova LDL-C3.27 ± 0.670.480.9730.0001
 Hattori LDL-C2.40 ± 0.86−0.390.9760.0001
 Anandaraja LDL-C2.60 ± 0.98−0.180.9780.0001
 Vujovic LDL-C3.05 ± 0.910.260.9780.0001
 Ahmadi LDL-C8.27 ± 0.805.480.7930.0001
 Puavillai LDL-C2.87 ± 0.920.070.9770.020
TG > 4.51 mmol/L (n = 65)
 Direct LDL-C2.59 ± 0.63  0.0001
 Friedewald LDL-C2.07 ± 1.06−0.520.8840.0001
 Chen LDL-C3.04 ± 0.830.440.8860.0001
 de Cordova LDL-C3.77 ± 0.801.170.6220.0001
 Hattori LDL-C1.92 ± 1.01−0.670.8820.0001
 Anandaraja LDL-C2.11 ± 1.13−0.480.9130.0001
 Vujovic LDL-C2.87 ± 0.950.270.9090.0001
 Ahmadi LDL-C11.88 ± 3.39.28−0.0530.0001
 Puavillai LDL-C2.56 ± 0.99−0.030.9060.592