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Table 3 Mean (±SD) values of calculated LDL-C by eight formulae for various HDL-C ranges and their correlation with directly measured LDL-C

From: Evaluation of eight formulas for LDL-C estimation in Iranian subjects with different metabolic health statuses

MethodMean ± SD (mmol/L)Mean Difference (mmol/L)Correlation (r)p-value obtained by paired t-test
HDL-C < 1.03 mmol/L (n = 382)
 Direct LDL-C2.22 ± 0.47   
 Friedewald LDL-C2.16 ± 0.67−0.050.9020.007
 Chen LDL-C2.38 ± 0.580.160.9110.0001
 de Cordova LDL-C2.44 ± 0.650.220.6750.0001
 Hattori LDL-C2.02 ± 0.63−0.190.8990.0001
 Anandaraja LDL-C2.04 ± 0.64−0.170.9010.0001
 Vujovic LDL-C2.45 ± 0.640.230.9400.0001
 Ahmadi LDL-C5.55 ± 0.673.330.1600.0001
 Puavillai LDL-C2.34 ± 0.640.120.9330.0001
HDL-C 1.03–1.52 mmol/L (n = 1837)
 Direct LDL-C2.54 ± 0.62   
 Friedewald LDL-C2.68 ± 0.740.130.9040.0001
 Chen LDL-C2.70 ± 0.710.160.9330.0001
 de Cordova LDL-C2.56 ± 0.680.020.9050.0001
 Hattori LDL-C2.51 ± 0.70−0.020.9030.0001
 Anandaraja LDL-C2.83 ± 0.700.290.8860.0001
 Vujovic LDL-C2.88 ± 0.770.330.9260.0001
 Ahmadi LDL-C4.72 ± 1.722.170.6310.0001
 Puavillai LDL-C2.80 ± 0.760.260.9330.0001
HDL-C ≥ 1.55 mmol/L (n = 533)
 Direct LDL-C2.70 ± 0.73   
 Friedewald LDL-C2.93 ± 0.850.230.9740.0001
 Chen LDL-C2.87 ± 0.820.160.9830.0001
 de Cordova LDL-C2.63 ± 0.76−0.060.9710.0001
 Hattori LDL-C2.75 ± 0.800.050.9730.0001
 Anandaraja LDL-C3.48 ± 0.790.770.9470.0001
 Vujovic LDL-C3.091 ± 0.890.380.9820.0001
 Ahmadi LDL-C4.32 ± 1.551.620.8060.0001
 Puavillai LDL-C3.03 ± 0.870.320.9800.0001