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Table 4 Mean (±SD) values of calculated LDL-C by eight formulae for various TC ranges and their correlation with directly measured LDL-C

From: Evaluation of eight formulas for LDL-C estimation in Iranian subjects with different metabolic health statuses

MethodMean ± SD (mmol/L)Mean Difference (mmol/L)Correlation (r)p-value obtained by paired t-test
TC < 5.17 mmol/L (n = 1903)
 Direct LDL-C2.22 ± 0.42   
 Friedewald LDL-C2.30 ± 0.520.080.8850.0001
 Chen LDL-C2.33 ± 0.470.110.9320.0001
 de Cordova LDL-C2.21 ± 0.43−0.010.8860.354
 Hattori LDL-C2.15 ± 0.49−0.060.8830.0001
 Anandaraja LDL-C2.48 ± 0.550.260.7600.0001
 Vujovic LDL-C2.21 ± 0.52−0.010.9230.0001
 Ahmadi LDL-C4.08 ± 1.211.860.4460.0001
 Puavillai LDL-C2.41 ± 0.520.190.9200.0001
TC 5.17–6.18 mmol/L (n = 634)
 Direct LDL-C3.05 ± 0.31   
 Friedewald LDL-C3.27 ± 0.470.210.7710.0001
 Chen LDL-C3.30 ± 0.300.240.7920.0001
 de Cordova LDL-C3.13 ± 0.290.070.4000.0001
 Hattori LDL-C3.06 ± 0.440.010.7690.327
 Anandaraja LDL-C3.48 ± 0.510.420.5840.0001
 Vujovic LDL-C3.51 ± 0.370.450.8090.0001
 Ahmadi LDL-C3.17 ± 1.650.12−0.2490.0001
 Puavillai LDL-C3.41 ± 0.400.360.8790.0001
TC ≥ 6.20 mmol/L (n = 215)
 Direct LDL-C3.72 ± 0.52   
 Friedewald LDL-C4.01 ± 0.910.290.7040.0001
 Chen LDL-C4.13 ± 0.610.410.6020.0001
 de Cordova LDL-C3.99 ± 0.540.270.1610.0001
 Hattori LDL-C3.76 ± 0.870.040.7050.337
 Anandaraja LDL-C4.24 ± 0.940.510.7190.0001
 Vujovic LDL-C4.36 ± 0.750.640.6680.0001
 Ahmadi LDL-C7.77 ± 2.924.05−0.4450.0001
 Puavillai LDL-C4.23 ± 0.810.510.6890.0001