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Table 5 Mean (±SD) values of calculated LDL-C by eight formulae for three FBS levels and their correlation with directly measured LDL-C

From: Evaluation of eight formulas for LDL-C estimation in Iranian subjects with different metabolic health statuses

MethodMean ± SD (mmol/L)Mean Difference (mmol/L)Correlation (r)p-value obtained by paired t-test
Non-diabetic: FBS < 5.49 mmol/L (n = 1505)
 Direct LDL-C2.49 ± 0.62   
 Friedewald LDL-C2.67 ± 0.770.170.9180.00001
 Chen LDL-C2.67 ± 0.720.170.9420.00001
 de Cordova LDL-C2.50 ± 0.680.010.9020.461
 Hattori LDL-C2.50 ± 0.720.010.9170.242
 Anandaraja LDL-C2.88 ± 0.800.380.8600.00001
 Vujovic LDL-C2.85 ± 0/780.350.9400.00001
 Ahmadi LDL-C4.43 ± 1.711.940.5630.00001
 Puavillai LDL-C2.78 ± 0.780.280.9350.00001
Pre-diabetic: FBS 5.55–6.93 mmol/L (n = 543)
 Direct LDL-C2.60 ± 0.62   
 Friedewald LDL-C2.72 ± 0.780.120.9360.00001
 Chen LDL-C2.77 ± 0.710.170.9610.00001
 de Cordova LDL-C2.65 ± 0.660.040.8930.00001
 Hattori LDL-C2.55 ± 0.73−0.050.9350.00001
 Anandaraja LDL-C2.89 ± 0.820.280.8870.00001
 Vujovic LDL-C2.94 ± 0.770.330.9610.00001
 Ahmadi LDL-C4.99 ± 1.842.380.4370.00001
 Puavillai LDL-C2.86 ± 0.770.250.9700.00001
Diabetic: FBS ≥ 6.99 mmol/L (n = 637)
 Direct LDL-C2.54 ± 0.66   
 Friedewald LDL-C2.56 ± 0.820.020.9370.043
 Chen LDL-C2.68 ± 0.770.140.9640.00001
 de Cordova LDL-C2.63 ± 0.740.080.8930.00001
 Hattori LDL-C2.40 ± 0.77−0.130.9360.00001
 Anandaraja LDL-C2.74 ± 0.870.200.8960.00001
 Vujovic LDL-C2.82 ± 0.830.270.9650.00001
 Ahmadi LDL-C5.31 ± 2.142.770.4920.00001
 Puavillai LDL-C2.72 ± 0.820.180.9580.026