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Table 5 Mean (±SD) values of calculated LDL-C by eight formulae for three FBS levels and their correlation with directly measured LDL-C

From: Evaluation of eight formulas for LDL-C estimation in Iranian subjects with different metabolic health statuses

Method

Mean ± SD (mmol/L)

Mean Difference (mmol/L)

Correlation (r)

p-value obtained by paired t-test

Non-diabetic: FBS < 5.49 mmol/L (n = 1505)

 Direct LDL-C

2.49 ± 0.62

   

 Friedewald LDL-C

2.67 ± 0.77

0.17

0.918

0.00001

 Chen LDL-C

2.67 ± 0.72

0.17

0.942

0.00001

 de Cordova LDL-C

2.50 ± 0.68

0.01

0.902

0.461

 Hattori LDL-C

2.50 ± 0.72

0.01

0.917

0.242

 Anandaraja LDL-C

2.88 ± 0.80

0.38

0.860

0.00001

 Vujovic LDL-C

2.85 ± 0/78

0.35

0.940

0.00001

 Ahmadi LDL-C

4.43 ± 1.71

1.94

0.563

0.00001

 Puavillai LDL-C

2.78 ± 0.78

0.28

0.935

0.00001

Pre-diabetic: FBS 5.55–6.93 mmol/L (n = 543)

 Direct LDL-C

2.60 ± 0.62

   

 Friedewald LDL-C

2.72 ± 0.78

0.12

0.936

0.00001

 Chen LDL-C

2.77 ± 0.71

0.17

0.961

0.00001

 de Cordova LDL-C

2.65 ± 0.66

0.04

0.893

0.00001

 Hattori LDL-C

2.55 ± 0.73

−0.05

0.935

0.00001

 Anandaraja LDL-C

2.89 ± 0.82

0.28

0.887

0.00001

 Vujovic LDL-C

2.94 ± 0.77

0.33

0.961

0.00001

 Ahmadi LDL-C

4.99 ± 1.84

2.38

0.437

0.00001

 Puavillai LDL-C

2.86 ± 0.77

0.25

0.970

0.00001

Diabetic: FBS ≥ 6.99 mmol/L (n = 637)

 Direct LDL-C

2.54 ± 0.66

   

 Friedewald LDL-C

2.56 ± 0.82

0.02

0.937

0.043

 Chen LDL-C

2.68 ± 0.77

0.14

0.964

0.00001

 de Cordova LDL-C

2.63 ± 0.74

0.08

0.893

0.00001

 Hattori LDL-C

2.40 ± 0.77

−0.13

0.936

0.00001

 Anandaraja LDL-C

2.74 ± 0.87

0.20

0.896

0.00001

 Vujovic LDL-C

2.82 ± 0.83

0.27

0.965

0.00001

 Ahmadi LDL-C

5.31 ± 2.14

2.77

0.492

0.00001

 Puavillai LDL-C

2.72 ± 0.82

0.18

0.958

0.026

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Lipids in Health and Disease

ISSN: 1476-511X