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Table 6 Mean (±SD) values of calculated LDL-C by eight formulae for various age ranges and their correlation with directly measured LDL-C

From: Evaluation of eight formulas for LDL-C estimation in Iranian subjects with different metabolic health statuses

Method

Mean ± SD (mmol/L)

Mean Difference (mmol/L)

Correlation (r)

p-value obtained by paired t-test

Age < 20 year (n = 100)

 Direct LDL-C

2.03 ± 0.50

   

 Friedewald LDL-C

2.14 ± 0.57

0.11

0.959

0.0001

 Chen LDL-C

2.13 ± 0.57

0.10

0.986

0.0001

 de Cordova LDL-C

1.99 ± 0.55

−0.03

0.974

0.006

 Hattori LDL-C

2.01 ± 0.53

− 0.02

0.957

0.105

 Anandaraja LDL-C

2.35 ± 0.59

0.31

0.862

0.0001

 Vujovic LDL-C

2.28 ± 0.60

0.24

0.981

0.0001

 Ahmadi LDL-C

3.50 ± 1.31

1.47

0.796

0.0001

 Puavillai LDL-C

2.22 ± 0.59

0.19

0.974

0.0001

Age 20–39 year (n = 623)

 Direct LDL-C

2.37 ± 0.61

   

 Friedewald LDL-C

2.51 ± 0.70

0.13

0.940

0.0001

 Chen LDL-C

2.53 ± 0.68

0.15

0.947

0.0001

 de Cordova LDL-C

2.39 ± 0.66

0.01

0.922

0.075

 Hattori LDL-C

2.35 ± 0.66

−0.01

0.938

0.043

 Anandaraja LDL-C

2.72 ± 0.72

0.34

0.853

0.0001

 Vujovic LDL-C

2.69 ± 0.72

0.32

0.974

0.0001

 Ahmadi LDL-C

4.35 ± 1.87

1.97

0.584

0.00001

 Puavillai LDL-C

2.62 ± 0.71

0.25

0.963

0.0001

Age between 40 to 59 year (n = 1138)

 Direct LDL-C

2.65 ± 0.61

   

 Friedewald LDL-C

2.78 ± 0.81

0.13

0.894

0.0001

 Chen LDL-C

2.83 ± 0.73

0.18

0.921

0.0001

 de Cordova LDL-C

2.70 ± 0.69

0.05

0.851

0.0001

 Hattori LDL-C

2.61 ± 0.76

−0.03

0.892

0.0001

 Anandaraja LDL-C

2.97 ± 0.85

0.32

0.858

0.0001

 Vujovic LDL-C

3.00 ± 0.80

0.35

0.921

0.0001

 Ahmadi LDL-C

5.05 ± 1.98

2.39

0.410

0.0001

 Puavillai LDL-C

2.92 ± 0.80

0.27

0.914

0.0001

Age ≥ 60 year (n = 891)

 Direct LDL-C

2.54 ± 0.64

   

 Friedewald LDL-C

2.65 ± 0.80

0.11

0.957

0.0001

 Chen LDL-C

2.69 ± 0.74

0.15

0.978

0.0001

 de Cordova LDL-C

2.57 ± 0.68

0.03

0.931

0.0001

 Hattori LDL-C

2.48 ± 0.75

−0.05

0.956

0.0001

 Anandaraja LDL-C

2.85 ± 0.84

0.30

0.899

0.0001

 Vujovic LDL-C

2.86 ± 0.80

0.31

0.977

0.0001

 Ahmadi LDL-C

4.81 ± 1.72

2.26

0.546

0.0001

 Puavillai LDL-C

2.78 ± 0.80

0.23

0.972

0.0001