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Table 6 Mean (±SD) values of calculated LDL-C by eight formulae for various age ranges and their correlation with directly measured LDL-C

From: Evaluation of eight formulas for LDL-C estimation in Iranian subjects with different metabolic health statuses

MethodMean ± SD (mmol/L)Mean Difference (mmol/L)Correlation (r)p-value obtained by paired t-test
Age < 20 year (n = 100)
 Direct LDL-C2.03 ± 0.50   
 Friedewald LDL-C2.14 ± 0.570.110.9590.0001
 Chen LDL-C2.13 ± 0.570.100.9860.0001
 de Cordova LDL-C1.99 ± 0.55−0.030.9740.006
 Hattori LDL-C2.01 ± 0.53− 0.020.9570.105
 Anandaraja LDL-C2.35 ± 0.590.310.8620.0001
 Vujovic LDL-C2.28 ± 0.600.240.9810.0001
 Ahmadi LDL-C3.50 ± 1.311.470.7960.0001
 Puavillai LDL-C2.22 ± 0.590.190.9740.0001
Age 20–39 year (n = 623)
 Direct LDL-C2.37 ± 0.61   
 Friedewald LDL-C2.51 ± 0.700.130.9400.0001
 Chen LDL-C2.53 ± 0.680.150.9470.0001
 de Cordova LDL-C2.39 ± 0.660.010.9220.075
 Hattori LDL-C2.35 ± 0.66−0.010.9380.043
 Anandaraja LDL-C2.72 ± 0.720.340.8530.0001
 Vujovic LDL-C2.69 ± 0.720.320.9740.0001
 Ahmadi LDL-C4.35 ± 1.871.970.5840.00001
 Puavillai LDL-C2.62 ± 0.710.250.9630.0001
Age between 40 to 59 year (n = 1138)
 Direct LDL-C2.65 ± 0.61   
 Friedewald LDL-C2.78 ± 0.810.130.8940.0001
 Chen LDL-C2.83 ± 0.730.180.9210.0001
 de Cordova LDL-C2.70 ± 0.690.050.8510.0001
 Hattori LDL-C2.61 ± 0.76−0.030.8920.0001
 Anandaraja LDL-C2.97 ± 0.850.320.8580.0001
 Vujovic LDL-C3.00 ± 0.800.350.9210.0001
 Ahmadi LDL-C5.05 ± 1.982.390.4100.0001
 Puavillai LDL-C2.92 ± 0.800.270.9140.0001
Age ≥ 60 year (n = 891)
 Direct LDL-C2.54 ± 0.64   
 Friedewald LDL-C2.65 ± 0.800.110.9570.0001
 Chen LDL-C2.69 ± 0.740.150.9780.0001
 de Cordova LDL-C2.57 ± 0.680.030.9310.0001
 Hattori LDL-C2.48 ± 0.75−0.050.9560.0001
 Anandaraja LDL-C2.85 ± 0.840.300.8990.0001
 Vujovic LDL-C2.86 ± 0.800.310.9770.0001
 Ahmadi LDL-C4.81 ± 1.722.260.5460.0001
 Puavillai LDL-C2.78 ± 0.800.230.9720.0001