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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet

Fig. 1

Decrease in the biliary cholesterol secretion in L1-Tg mice. a Immunoblot detection of hepatic NPC1L1 protein in L1-Tg mice using an anti-NPC1L1 antibody. WT, wild-type. b Lower rates of biliary cholesterol secretion in L1-Tg mice fed a high-fat diet (HFD) for 2 weeks than those in WT mice. c Bile flow. d Biliary secretion of bile acids. e Biliary secretion of phospholipids. Data are expressed as the mean ± SEM. n = 4 (WT), 6 (L1-Tg). Statistical analyses for significant differences were performed using a two-sided t-test (††, P < 0.01; NS, not significantly different between groups)

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Lipids in Health and Disease

ISSN: 1476-511X