| All | ABCG5/8 mutations |  | |
---|---|---|---|---|
Variable | (n = 321) | YES (n = 26) | NO (n = 295) | p value |
Age (years) | 51 ± 18 | 52 ± 13 | 51 ± 16 | n.s. |
Gender (male/female) | 172/142 | 12/14 | 160/135 | n.s. |
Hypertension | 92 (29%) | 7 (27%) | 85 (29%) | n.s. |
Diabetes | 118 (37%) | 9 (35%) | 109 (37%) | n.s. |
Smoking | 70 (22%) | 5 (19%) | 65 (22%) | n.s. |
Weighted polygenic score | 0.53 ± 0.10 | 0.46 ± 0.11 | 0.54 ± 0.10 | < 0.05 |
Baseline LDL-cholesterol (mg/dl) | 192 ± 46 | 194 ± 56 | 191 ± 41 | n.s. |
LDL-cholesterol (mg/dl) under atorvastatin 10 mg/day | 121 ± 48 | 121 ± 45 | 120 ± 34 | n.s. |
LDL-cholesterol (mg/dl) under atorvastatin 10 mg/day + ezetimibe 10 mg/day | 83 ± 30 | 72 ± 26 | 87 ± 29 | < 0.05 |